综合征与非综合征型腭裂患者颅颌面结构特征的对比研究  

Comparative Research of Craniofacial Structural Characteristics of Syndromic and Non-syndromic Patients with Cleft Palate

作　　者：鲁大为[1] 石冰[1] 王衡健[1] 郑广宁[2] 王虎[2] 郑谦[1] 

机构地区：[1]四川大学华西口腔医院唇腭裂外科,四川成都610041 [2]四川大学华西口腔医院放射科,四川成都610041

出　　处：《华西口腔医学杂志》2007年第1期50-54,共5页West China Journal of Stomatology

基　　金：四川省科技攻关资助项目(03SG022-002)

摘　　要：目的比较和认识综合征型与非综合征型腭裂患者颅颌面结构的差异和特点,揭示综合征型腭裂患者上下颌骨生长发育的规律以及腭裂与颌面部其他畸形之间的关系。方法采集符合特定条件的混合牙列期男性腭裂患者57例,其中Treacher Collins综合征8例,Pierre Robin综合征9例、非综合征型腭裂患者40例。所有患者行侧位头影测量检查,对侧位片进行定点分析并且选择18项指标进行测量,使用SPSS12.0软件对其结果进行统计学分析。结果与非综合征型腭裂患者相比,综合征型腭裂患者下颌骨生长发育的差异主要表现为SNB的减小和ANB的增大(P<0.05),提示综合征型腭裂患者下颌骨在前后方向上的发育较非综合征型腭裂患者相对不足;而两组患者的上颌骨前后向发育无统计学差异(P>0.05),颅底的生长发育亦无统计学差异(P>0.05)。结论综合征型腭裂患者的上颌骨形态结构以及生长发育与非综合征型腭裂患者基本类似,两者之间存在着相似的生长发育潜力;腭裂患者颅颌面诸骨的生长发育既相互影响又相对独立。Objective To compare craniofacial structural characteristic of syndromic and non-syndromic patients with cleft palate and to probe into the reason of their maxillary hypoplasia and to lay a foundation for better treatment protocol for syndromic patients with cleft palate. Methods The sample consisted of 8 individuals with Treacher Collin syndrome, 9 patients with Pierre Robin syndrome, and 40 patients with non-syndromic cleft palate which met certain criterions. Lateral cephalometric radiographs were obtained from each study subject. A total of 18 variables, comprising 9 angular, 7 linear, and 2 ratio measurements, were studied. SPSS 12.0 software was used to describe the statistics data, consisting of means, SD, and t test. Results The tendency for smaller value in SNB and larger value in ANB indicate a severer anteroposterior mandibular hypoplasia in the syndromic type cleft. There was no difference between syndromic and non-syndromic cleft palate patients with regards to maxillary anteroposterior development. No significant difference on the development in cranial base area was found either. Conclusion This interplay of cranio-facial bones is very important in the development of this complex, which will not only affect the growth but also the defect development. In this study, the patients with the two syndromes showed the similar growth potential of maxilla with the non-syndromic cleft patients.

关 键 词：腭裂 TREACHER COLLINS综合征 PIERRE ROBIN综合征 头影测量 

分 类 号：R782.2[医药卫生—口腔医学]