酰基辅酶A:胆固醇酰基转移酶抑制剂Beauveriolide I的全合成  

Total Synthesis of Acyl-CoA:Cholesterol Acyltransferase Inhibitor Beauveriolide I

作　　者：田华[1] 焦晓臻[1] 谢平[1] 梁晓天[1] 

机构地区：[1]中国协和医科大学中国医学科学院药物研究所,北京100050

出　　处：《有机化学》2007年第1期103-108,共6页Chinese Journal of Organic Chemistry

摘　　要：报道了酰基辅酶A:胆固醇酰基转移酶抑制剂beauveriolideI的全合成.BeauveriolideI结构中的饱和脂肪酸具有两个相邻的手性中心,是合成的关键中间体,以(4R)-4-苄基-3-丙酰基-2-噁唑烷酮和3-苄氧丙醛为起始原料制备得到.Beauveriolide I的结构经1HNMR,13CNMR,MS和IR谱确定.The total synthesis of beauveriolide I, an inhibitor of acyl-CoA： cholesterol acyltransferase （ACAT）, was described. The fatty acid moiety with two contiguous chiral centers in beauveriolide I, a key intermediate, has been prepared via （4R）-4-benzyl-3-propionyl-2-oxazolidinone and 3-benzyloxypropio- naldehyde as starting materials. The structure of beauveriolide I was confirrmed by ^1H NMR, ^13C NMR, MS and IR spectra.

关 键 词：胆固醇酰基转移酶抑制剂 beauveriolide I 全合成 

分 类 号：TQ464.8[化学工程—制药化工]