遗传性非息肉病性大肠癌（附10个家族报告）  

Hereditarynonpolyposiscolorectalcancer.Areportof10familiesMo

作　　者：莫善兢[1] 蔡宏[1] 蔡三军[1] 师英强[1] 傅红[1] 陈瑞武[1] 

机构地区：[1]上海医科大学肿瘤医院

出　　处：《中华消化杂志》1996年第6期326-328,共3页Chinese Journal of Digestion

摘　　要：遗传性非息肉病性大肠癌又称Ｌｙｎｃｈ综合征。患者之子女中５０％将受遗传而发病。在全部大肠癌患者中约５％属该病。在确诊的１０个Ｌｙｎｃｈ综合征家族。有３７例患大肠癌。平均发病年龄为４４．８岁（２０－７３岁）。３７例共已患５１个大肠癌，其中８２．３％为结肠癌，５６．９％位于脾曲近侧结肠，２０．２％有多原发大肠癌。文章强调了及早识别该病与随访的意义，以及诊断、治疗的特点。Hereditarynonpolyposiscolorectalcancer(HNPCC)isalsocalledLynchsyndrome.50%* ofpatients'childrenwillbecomevictumsofcolorectalcancer.Itaccountsfor5%* oftotalcolorectalcancer.Thereareseveralcharacteristicfeatureswhicharefullypresentedinthepaper.Weascertained10familieswithLynchsyndrome.Therewere37casesofcolorectalcancer,themeanageofonsetwas44.8years(20-73years).In37cases,51colorectalcancerswerefound,amongwhich82.3%*妉ocatedincolon,56.9%* proximaltosplenicflexure.20.2%* hadmultipleprimarycolorectalcancer.Thearticleemphasizedonthesignificanceofearlyrecognitionandfollow-upstudy,theircharacteristicfeaturesindiagnosisandwayoftreatment.

关 键 词：结肠直肠肿瘤 遗传性 非息肉病 大肠肿瘤 治疗 

分 类 号：R735.340.5[医药卫生—肿瘤]