酵母菌全葡聚糖颗粒β-葡聚糖联合抗瘤单克隆抗体治疗肿瘤  

Yeast β-glucan in conjunction with antitumour monoclonal antibodies to treat cancer

作　　者：刘艳[1] 张瑾[1] 

机构地区：[1]天津医科大学附属肿瘤医院乳腺三科,天津300060

出　　处：《国际外科学杂志》2007年第3期181-185,共5页International Journal of Surgery

摘　　要：β-葡聚糖是来源于酵母菌全葡聚糖颗粒和其它来源细胞壁的生物效应调节剂（BRMs），用于启动白细胞补体受体3（CR3），从而使这些细胞可以杀伤补体片段iC3b调理的肿瘤细胞。大量动物肿瘤模型研究显示，口服微粒酵母菌β-葡聚糖与抗肿瘤单克隆抗体的联合治疗在肿瘤退化和长时间生存方面有效。β-葡聚糖能提高抗肿瘤单克隆抗体临床治疗的有效性。Beta-glucans, biological response modiflers（BRMs） derived from the cell walls of yeast and other sources, have been demonstrated to prime leukocyte complement receptor 3 （ CR3 ）, thus enabling these cells to kill tumours opsonized with complement fragment iC3b. Many turnouts activate complement via the classical pathway mediated by antitumour monoclonal antibodies （ mAbs ） or natrual antibodies. Yeast β-glucans teken could be ingested and processed by macrophages; these macrophages secreted the active moiety that primes neutrophil CR3 to kill iC3b-opsordsed tumour cells. Combination of oral particulate yeast β-giucan with antitumour mAb was effective terms of tumour regression and long-term survival. It is proposed that the addition of β-glucan will enhance the therapeutic efficacy of antitumour mAbs in cancer patients.

关 键 词：Β-葡聚糖 抗肿瘤单克隆抗体 生物效应调节剂 补体受体3 免疫治疗 

分 类 号：R730[医药卫生—肿瘤]