上皮肿瘤始于干细胞  

Epithelial tumor development from stem cells

作　　者：孙红玉[1] 胡凯猛[1] 刘厚奇[1] 

机构地区：[1]第二军医大学基础医学部组织胚胎学教研室,上海200433

出　　处：《生命科学》2007年第1期27-30,共4页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金(90208026)

摘　　要：人类肿瘤大约90%以上源自于上皮。上皮干细胞是唯一长期存在于上皮组织的细胞,可积累多次突变生成肿瘤。所以,人们认为肿瘤多起源于正常干细胞。然而,目前研究中关于上皮肿瘤干细胞及其与正常上皮干细胞的关系了解甚少。现综述近年来有关上皮干细胞和肿瘤发生的关系及其调控机制方面的研究进展。Over 90% of all human neoplasia is derived from epithelia. Being long-term residents in epithelium, stem cells are uniquely susceptible to the accumulation of multiple oncogenic changes giving rise to tumors. So it is generally assumed that tumor cells are derived from normal stem cells, more work is needed to identify and characterize epithelial tumor stem cells. This article reviews the relationship and regulatory mechanism between normal stem cells and epithelial tumor stem cells.

关 键 词：上皮干细胞 肿瘤前演进 肿瘤干细胞 

分 类 号：Q24[生物学—细胞生物学] R730.2[医药卫生—肿瘤]