P63 Actin CK在乳腺原位癌及早期浸润性癌鉴别诊断中的意义  

The Significance of Expression of P63,Actin,CK in the Differential Diagnosis of Breast Carcinoma in Situ or Early Invasive Carcinoma

作　　者：李玉红[1] 尹艳华[1] 许俊龙[1] 王永生[1] 任玉波[1] 

机构地区：[1]聊城市人民医院,山东聊城252000

出　　处：《实用医技杂志》2007年第4期456-457,共2页Journal of Practical Medical Techniques

摘　　要：目的:探讨单克隆抗体P63 Actin CK在乳腺原位癌及早期浸润性癌中的表达及意义。方法:采用免疫组化Elivision法检测18例乳腺原位癌,24例乳腺早期浸润性癌中P63 Actin CK的表达。结果:24例乳腺早期浸润性癌中,3例在硬化间质内的“浸润”成分,IHC示CK(+)的细胞周边有P63(+)Actin(+)的肌上皮细胞围绕,而18例乳腺原位癌中2例在间质内发现CK(+)的细胞,周边无P63(+)Actin(+)的肌上皮细胞围绕。结论:P63作为标记肌上皮细胞敏感特异的抗体,极少数报道腺上皮细胞亦着色,但结合Actin的表达和HE切片,可以区分,CK P63 Actin三者联合应用,有助于鉴别间质内为浸润的腺体,还是挤压的导管,以辅助乳腺原位癌及早期浸润癌的诊断及鉴别诊断。Objective To explore the significance of expression of P63, Actin, CK in the diagnosis and differential diagnosis of breast carcinoma in situ or early invasive careinoma. Methods Elivision labeling technique was used to study expression of P63 Actin CK in 18 cases of breast carcinoma in situ and 24 cases of early invasive carcinoma. Results Three of 24 cases early invasive carcinoma showed CK Actin and P63 positive for＂invasing findings＂in stroma,two of 18 cases carcinoma in situ showed CK positive and P63 Actin negtive. Conclusion P63 was able to label myoepithelral cells with high sensitivity and specificity and can different glandular epithelium from ductual complent with CK Actin and HE section,despite of few glandular epithelium was positive for P63. It could be maken a important way to diagnosis the carcinoma in situ or early invasive carcinoma.

关 键 词：原住癌 早期浸润 P63 ACTIN CK 

分 类 号：R737.9[医药卫生—肿瘤]