Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers  

作　　者：Zhen Ying Li Zhao Sheng Liu Qing Wei Zhang Hong Quan Duan 

机构地区：[1]School of Pharmaceutical Sciences, Tianjin Medical University, Tw.njin 300070, China [2]Basic Medical Research Center of Ttanjin, Ttanjin Medical University, Ttanjin 300070, China

出　　处：《Chinese Chemical Letters》2007年第3期322-324,共3页中国化学快报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(20575045);outstanding scholar programs of Tianjin Medical University(to Z.S.Liu).

摘　　要：Molecularly imprinted polymers （MIPs）, using （S）-naproxen as template and the combination of butyl methacrylate （BMA） and MAA （1：1 molar ratio） as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen （Rs = 1.55） and column efficiencies of imprinted molecules （N = 2860 plates/m） than that with pure MAA.Molecularly imprinted polymers （MIPs）, using （S）-naproxen as template and the combination of butyl methacrylate （BMA） and MAA （1：1 molar ratio） as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen （Rs = 1.55） and column efficiencies of imprinted molecules （N = 2860 plates/m） than that with pure MAA.

关 键 词：Molecularly imprinted polymer Monolithic column NAPROXEN Chiral separation 

分 类 号：R914.5[医药卫生—药物化学]