山茱萸环烯醚萜苷对局灶性脑缺血模型大鼠神经功能和神经元损伤的影响  

Effects of Cornel Iridoid Glycoside on Nervous Function and Neuron Damage in Focal Cerebral Ischemic Rats

作　　者：张丽[1] 李春阳[2] 赵玲[1] 王文[1] 张兰[1] 李林[1] 

机构地区：[1]首都医科大学宣武医院药物研究室教育部神经变性病学重点实验室,北京市100053 [2]内蒙古医学院第一附属医院神经内科,内蒙古呼和浩特市010059

出　　处：《中国康复理论与实践》2007年第3期201-202,f0003,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家重点基础研究发展计划-973计划项目(2003CB517104);国家自然科学基金项目(34072184);北京市自然科学基金项目(7050001;7032013);北京市科技新星计划B类(H020821390190);北京市科技计划项目(D0204003000031);首都医学发展科研基金项目(首发03III21)。

摘　　要：目的观察山茱萸环烯醚萜苷(CIG)对大脑中动脉阻塞法(MACO)致脑缺血再灌注模型大鼠神经功能和神经细胞的影响。方法用线栓法制备局灶性脑缺血大鼠模型,缺血2h再灌注24h。采用评分法检测神经功能改变,用尼氏染色的方法检测梗死灶神经元的变化。结果模型组与假手术组相比,神经症状评分明显升高,梗死灶神经元数量明显减少。与模型组相比,CIG灌胃口服能够明显降低模型大鼠神经症状评分,增加梗死灶神经元的存活数量。结论CIG对大鼠局灶性脑缺血有明显改善作用。Objective To observe the effects of cornel iridoid glycoside （CIG） on nervous function and neuronal survival in focal cerebral ischemic rat model. Methods The animal model was induced by occlusion of middle cerebral artery with suture embolus. Nervous function defect and survival number of neuron were detected with nervous function score and Nissl＇s staining respectively. Results Compared with Sham operation group, nervous function score increased and nervous survival number decreased obviously in model rats. Compared with model group, CIG decreased nervous function score and increased survival neurons significantly. Conclusion CIG may have theraoutic effect on cerebral infarct through improving nervous function and increasing survival neurons.

关 键 词：山茱萸环烯醚萜苷 脑梗死 神经功能评分 神经元存活 

分 类 号：R743.32[医药卫生—神经病学与精神病学]