PTEN基因在宫颈癌中的表达及与预后的关系  

Expression of PTEN Gene in Cervical Cancer and Its Relationship with Prognosis

作　　者：周琦[1] 叶学正[1] 唐郢[1] 黄海萍[1] 张代奎[1] 

机构地区：[1]重庆市肿瘤研究所,重庆400030

出　　处：《肿瘤学杂志》2007年第2期121-122,共2页Journal of Chinese Oncology

基　　金：重庆市卫生局资助项目(编号:局03-2-006)

摘　　要：[目的]探讨PTEN在宫颈癌中的表达及与宫颈癌预后的关系。[方法]选取该院1994～2003年间收治的79例宫颈鳞癌及1994～2004年间宫颈上皮内瘤样病变(CIN)切片79例,正常子宫颈切片16例。用免疫组化(S-P)的方法对其PTEN基因表达进行检测。比较PTEN在正常子宫颈、宫颈CIN及宫颈癌中表达的差异,分析PTEN与宫颈癌患者临床病理特点及预后的关系。[结果]正常宫颈PTEN表达阳性率为93.75%(15/16),CIN为58.23%(46/79),宫颈癌为37.97%(30/79),差异有显著性(P<0.05)。宫颈癌患者的淋巴转移与PTEN表达显著相关(P<0.05)。宫颈癌患者的年龄、分期、病理分级、预后与PTEN表达无显著相关性。多因素COX回归分析显示,PTEN并非独立的预后影响因素。[结论]PTEN基因在宫颈组织从癌前病变向宫颈癌演变的过程中有重要作用;PTEN基因表达与宫颈癌患者的淋巴转移显著相关,不是宫颈癌的独立预后影响因素。[Purpose] To explore the expression of PTEN in cervical cancer and its relationship with prognosis. [Methods]Immunohistochemical S-P method was used to detect the expression of PTEN gene in cervical squamous carcinoma tissues of 79 cases, CIN tissues of 79 cases, and normal cervical tissues of 16 cases in Chongqing Cancer Hospital. PTEN expressive differentiation among them and their relationship with clinicopathology and prognosis was analyzed. [Results] The PTEN positive expression rate was 93.75%（15/16） in normal cervix tissues,58.23% （46/79） in CIN tissues; and 37.97%（30/79） in cervical squamous carcinoma tissues, with significant difference （P〈0.05）. A significant association was found between the PTEN expression and lymph node metastasis （P〈0.05）. There was no significant correlation between PTEN expression and the patients＇ age, stage, grade and prognosis. Multivariate COX regression analysis showed that PTEN was not an independent prognostic factor. [Conclusion] PTEN gene plays an important role in progression from CIN to cervical cancer. PTEN expression is significantly correlated with lymph node metastasis, but is not an independent prognostic factor.

关 键 词：PTEN基因 宫颈上皮内瘤样病变 宫颈肿瘤 基因表达 预后 

分 类 号：R737.33[医药卫生—肿瘤]