内凝聚法制备姜油树脂海藻酸钙微囊  

Preparation of Calcium Alginate Microcapsules Loaded with Ginger Oleoresin by Internal Gelation Method

作　　者：刘利萍[1] 毛威 王秀珍[1] 裘汉幸 

机构地区：[1]绍兴文理学院化学化工学院药学系 [2]绍兴市药品检验所,浙江绍兴312000

出　　处：《中国医药工业杂志》2007年第4期285-287,共3页Chinese Journal of Pharmaceuticals

基　　金：浙江省青年教师2004年资助计划项目(浙教高科[2004]281)

摘　　要：姜科植物姜（Zingiber officinale Roscoe）的干燥根茎具有抗氧化、降胆固醇、抗运动病、止痛抗炎及止吐等多种药理作用。用超临界CO2萃取得到的姜油树脂（ginger oleoresin，1）为深琥珀色黏稠液体，有较强的辛辣刺激性，主要成分为姜酚（gingerol）、姜烯酚、姜油酮等化合物。其中姜酚可作为评价1药用品质的主要指标之一。The ginger oleoresin microcapsules were prepared by emulsification-internal gelation technique using sodium alginate as material. In vitro release behavior of the microcapsules was investigated under HCl and PBS. The results showed that the microcapsules observed with scanning electron microscope were spherical with mean diameter of （50.35±0.42）μm, span of 0.83±0.07 and drug entrapped efficiency of （45.3±0.4） % determined by UV method. The accumulative released amount was less than 10% in pH 1.2 hydrochloric acid within first 2h, but was up to about 83 % in pH 7.4 phosphate buffer solution in the following 4h. The product had the characteristic to dissolve the intestines.

关 键 词：姜油树脂 海藻酸钙 凝聚法 超临界CO2萃取 微囊 制备 姜科植物 降胆固醇 

分 类 号：TQ028.32[化学工程]