Axin在肿瘤发生中的作用机制  

Mechanism of Tumorigenesis Regulated by Axin

作　　者：金利华[1,2] 李勤喜[1,2] 叶志云[1,2] 

机构地区：[1]厦门大学医学院生物医学工程研究中心,厦门361005 [2]厦门大学生命科学学院生物医学科学系,厦门361005

出　　处：《细胞生物学杂志》2007年第2期207-212,共6页Chinese Journal of Cell Biology

摘　　要：阐明肿瘤发生机制的细胞信号转导途径的研究是当今生物医学领域研究的热点。Axin是一个肿瘤抑制因子,它以构架蛋白的形式在Wnt、JNK、p53、TGF-β、G蛋白信号转导途径等众多信号转导途径中参与细胞生长、增殖、分化、癌变和凋亡等多种重要细胞命运的调控过程。现从Axin的发现、Axin通过多种信号转导途径抑制肿瘤发生和AXIN1基因突变与肿瘤发生之间的关系这三个方面介绍肿瘤抑制因子Axin与肿瘤之间的研究进展。Ceil signaling pathways involved in tumorigenesis are the focus of biomedical research nowadays. Axin, a tumor suppressor, is an essential scaffold protein participating in a network of separate but interacting signaling transduction pathways. Emerging evidence indicates its diverse roles in Wnt, JNK, p53, TGF and Gprotein signaling pathways to regulate cellular fate determination, growth and proliferation. In this light, there has been intense investigation into the pivotal nature of Axin in assuring appropriate cell cycle progression and the detrimental effect of AXIN1 mutation that leads to human cancer. This review starts from the original identification of Axin and introduces the tumor suppressor roles of Axin in multiple signaling pathways with the emphasis on reported mutational study of AXIN1 gene in human tumorigenesis.

关 键 词：AXIN 信号转导 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]