Recent advances in basic and clinical aspects of inflammatory bowel disease: Which steps in the mucosal inflammation should we block for the treatment of inflammatory bowel disease?  

作　　者：Hitoshi Asakura Kenji Suzuki Terasu Honma 

机构地区：[1]Director of International Medical Information Center Emeritus Professor at Niigata University,Japan [2]Department of Internal Medicine Niigata University Medical and Dental Hospital,Japan [3]Department of Internal Medicine Niigata Prefectural Shibata Hospital,Japan

出　　处：《World Journal of Gastroenterology》2007年第15期2145-2149,共5页世界胃肠病学杂志（英文版）

摘　　要：There are four steps in the interaction between intestinal microbes and mucosal inflammation in genetically predisposed individuals from the viewpoints of basic and clinical aspects of inflammatory bowel disease （IBD）. The first step is an interaction between intestinal microbes or their components and intestinal epithelial cells via receptors, the second step an interaction between macrophages and dendritic cells and mucosal lymphocytes, the third step an interaction between lymphocytes and vascular endothelial cells, and the fourth step an interaction between lymphocytes and granulocytes producing proinflammatory cytokines or free radicals and mucosal damage and repair. Recent therapeutic approaches for IBD aim to block these four steps in the intestinal inflammation of patients with IBD.在从煽动性的肠疾病(IBD ) 的基本、临床的方面的观点的遗传上预先安排的个人在在肠的微生物和粘膜发炎之间的相互作用有四步。第一步经由受体是在肠的微生物或他们的部件和肠的上皮细胞之间的一个相互作用，第二走在巨噬细胞和树枝状的房间和粘膜淋巴细胞之间的一个相互作用，第三走在淋巴细胞和脉管的 endothelial 之间的一个相互作用，并且第四走在生产专业版的淋巴细胞和 granulocytes 之间的一个相互作用煽动性的 cytokines 或自由基和粘膜损坏和修理。为 IBD 的最近的治疗学的途径试图与 IBD 在病人的肠的发炎堵住这四步。

关 键 词：Ulcerative colitis Crohn＇s disease inflammatorγ bowel disease TREATMENT IMMUNOLOGY 

分 类 号：R574[医药卫生—消化系统]