Development of multiple myeloma in a patient with gastrointestinal stromal tumor treated with imatinib mesylate:a case report  

作　　者：D Tzilves A Gatopoulou A Tarpagos I Katsos K Zervas E Katodritou F Patakiouta 

机构地区：[1]Department of Gastroenterology, Theagenio Cancer Hospital, 2 Al. Simeonidi 54007, Thessaloniki, Greece [2]Department of Hematology, Theagenio Cancer Hospital, 2 Al. Simeonidi 54007, Thessaloniki, Greece [3]Department of Pathology, Theagenio Cancer Hospital, 2 Al. Simeonidi 54007, Thessaloniki, Greece

出　　处：《World Journal of Gastroenterology》2007年第13期2011-2013,共3页世界胃肠病学杂志（英文版）

摘　　要：Gastrointestinal stromal tumors (GISTs) are rare tumors, which represent approximately 1% of the neoplasms of the gastrointestinal tract. These tumors rarely give extra-abdominal metastases. However, their clinical outcome is potentially adverse. In some rare cases, co- existance of GISTs with other malignancies has been reported. Here we present a case of a 74-year old male with GIST, which was managed by surgical resection. Fourteen months later, the patient presented with liver metastases and imatinib mesylated was administered. During treatment, the patient reported skeletal pain and plane X-rays revealed osteolytic bone lesions. Further investigation revealed the presence of multiple myeloma. To the best of our knowledge, this is the first report of the co-existence of multiple myeloma (MM) with GIST.Gastrointestinal stromal tumors （GISTs） are rare tumors, which represent approximately 1% of the neoplasms of the gastrointestinal tract. These tumors rarely give extra-abdominal metastases. However, their clinical outcome is potentially adverse. In some rare cases, coexistance of GISTs with other malignancies has been reported. Here we present a case of a 74-year old male with GIST, which was managed by surgical resection. Fourteen months later, the patient presented with liver metastases and imatinib mesylated was administered. During treatment, the patient reported skeletal pain and plane X-rays revealed osteolytic bone lesions. Further investigation revealed the presence of multiple myeloma. To the best of our knowledge, this is the first report of the co-existence of multiple myeloma （MM） with GIST.

关 键 词：Gastrointestinal stromal tumor MULTIPLEMYELOMA Imatinib mesylate 

分 类 号：R735[医药卫生—肿瘤]