重离子束注入与生物体的相互作用及遗传诱变的分子机制  

Molecular Mechanism of Mutagenesis and Interaction of Incident Ions with Organism Implanted by Heavy Ions Beam

作　　者：李珂[1] 张东正[2] 赵瑾[1] 张根发[1] 

机构地区：[1]北京师范大学生命科学院,北京100875 [2]上海交通大学物理系,上海200030

出　　处：《原子核物理评论》2007年第2期117-123,共7页Nuclear Physics Review

基　　金：国家自然科学基金资助项目(30570434;10435020)~~

摘　　要：低能重离子与生物体系相互作用及其生物诱变效应的应用研究在我国率先兴起,并在应用中取得了很大的成就。介绍了重离子注入与生物有机体的相互作用及其主要的生物学效应,包括细胞染色体水平、生理生化效应,以及对DNA损伤修复、基因表达、甲基化修饰的影响。总结了离子注入诱变的分子遗传学机理的相关研究。同时分析、比较讨论了高能与低能离子、离子束与射线的生物学效应的异同。提出了离子注入今后的研究方向,特别指出了离子注入对生物基因表达影响研究的重要性。As a new mutagenesis technique, low energy heavy ion implantation started in China for the study of interaction effect between incident ions and organism, and great achievements have been obtained in crop breeding. The article reviewed the main biological effects induced by heavy ion implantation, including physiology, biochemistry and genetics effects, on levels of cell and chromosome, gene expression, DNA methylation, DNA damage and reparation etc. It compared the differences in mutagenesis for organism by high energy and low energy ion implantation, as well as γ ray radiaiton. Future investigation topics were proposed, the emphasis of researches in future was pointed out, i. e. , the molecular mechanism and effects of gene differential expression of organism treated by ion implantation.

关 键 词：离子注入 DNA损伤与修复 DNA修饰 遗传诱变 突变热点 

分 类 号：O691[理学—化学]