营养素摄入水平与前列腺癌发病因素的相关分析  

An analysis of risk for prostate cancer with nutrient intake

作　　者：安宁[1] 陈彤[2] 李登新[3] 

机构地区：[1]济南市卫生局卫生监督所,山东济南250001 [2]济南市中医医院针灸科,山东济南250000 [3]潍坊市人民医院消化内科,山东潍坊261000

出　　处：《中华肿瘤防治杂志》2007年第11期818-820,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的：探讨营养素摄入水平与前列腺癌发病危险的关系。方法：对经病理组织学确诊的96例前列腺癌新发病例实施1∶3配比的病例-对照研究。三类对照共计288例（其中医院癌对照96例,医院非癌对照96例,正常对照96例）。配比条件为同性别、同民族和年龄相差≤±5岁。结果：经条件Logistic回归分析结果显示,总热量（OR值1.22-2.06,P值分别为0.78、0.04和0.032）、总脂肪（OR值1.06-1.89,P值分别为0.98、0.021和0.019）、饱和脂肪酸（OR值1.08-1.79,P值分别为0.92、0.023和0.032）、不饱和脂肪酸（OR值1.07-2.81,P值分别为0.88、0.027和0.007 1）以及动物脂肪（OR值1.14-2.56,P值分别为0.87、0.047和0.008）与前列腺癌发病危险呈正相关;硒与前列腺癌发病危险呈负相关（OR值0.57-0.84,P值分别为0.84、0.031和0.030）。总热量、总脂肪、饱和脂肪酸、动物脂肪与前列腺癌发病存在一定的剂量反应关系。结论：营养素摄入过程中的高脂和微量元素硒缺乏与前列腺癌发病危险存在关联。OBJECTIVE： To explore the relationship between the nutrient intake and prostate cancer risk. METHODS： A hospital-based case-control study was conducted in 5 hospitals in Jinan A total of 96 cases of prostatic cancer histologically confirmed between 1997 and 1999 and 288 controls （96 hospitalized cases of other cancers, 96 hospitalized non-cancer cases and 96 neighborhood controls） of comparable age, sex and nationality were included interviewed and in the study. RESULTS： In an analysis using logistic regression, the following nutrient intakes were found to be related to the incidence of prostate cancer： total energy （OR = 1.22 - 2.06, P = 0.78, 0.04, 0. 032）, total fat （OR= 1.06-1.89, P=0. 98,0. 021,0. 019）, saturated fatty acid （OR= 1.08- 1.79, P= 0.92, 0.023, 0.032）, unsaturated fatty acid （OR=1.07-2.81, P=0.88, 0.027,0.007 1）, animal fat （OR= 1.14-2.56, P=0.87, 0. 047, 0. 008） showed positive association with prostate cancer, selenium （OR= 0.57-0.84, P= 0.84,0.031,0.030） showed a negative association. The trend tests showed that there might he a dose response between prostate cancer and total energy, total fat, saturated fatty acid and animal fat. CONCLUSION： High quantity fat and lack of selenium may have an association with prostatic cancer.

关 键 词：前列腺肿瘤/流行病学 营养 病例对照研究 

分 类 号：R737.25[医药卫生—肿瘤]