横纹肌溶解及其致急性肾功能衰竭的临床与病理特点(附1例报告)  

Clinical and pathological features of rhabdomyolysis and it caused acute renal failure: a case report

作　　者：李大年[1] 郑国玲[2] 刘淑萍[1] 任守臣[1] 

机构地区：[1]山东大学齐鲁医院神经肌肉病研究室,济南250012 [2]山东大学西校区医院

出　　处：《临床神经病学杂志》2007年第3期185-187,共3页Journal of Clinical Neurology

摘　　要：目的探讨横纹肌溶解(RM)及其致急性肾功能衰竭(ARF)的病因、病理、发病机制及治疗。方法对1例RM-ARF患者的临床和病理资料结合文献加以分析。结果此例患者有运动诱发性RM史5年,本次因饮酒及感染诱发RM-ARF。肌肉活检显示非特异性炎性改变。治疗RM以防止血容量降低和尿液酸化为原则,治疗ARF选择血液透析(HD),本例基本痊愈。结论本例病因系在原有运动诱发性RM基础上,因饮酒及感染而导致RM-ARF。应用肌肉活检,不但可观察到RM的典型形态学表现,并有助于病因的鉴别。及时应用HD治疗是本例获得良好疗效的关键。Objective To investigate the etiology, pathology, pathogenesy and treatment in patient with rhabdomyolysis （ RM ） complicated with acute renal failure （ ARF ）. Methods Analysis of clinical and muscle pathological data combined with literatures were made for a patient with RM-ARF. Results The patient who bad experienced exercise induced RM for 5 years. Alcohol drinking and infection were led to RM with ARF for this time. There was non-special inflammatory feature in light microscope by biopsy. The principle of RM management was prevention of hypovolemia and acidification of urine. Hemodialysis （HD）was chosen for treatment of ARF and basic recovery was obtained. Conclusions The etiology of this patient may be the alcohol drinking, particularly the infection which developed on the basis of recurrent RM. Muscle biopsy is useful not only for observing the pathological features of RM, but also for differentiation of etiological factors. The HD therapy used in time may be the key to get favorable effect for this case.

关 键 词：横纹肌溶解 肌肉病理 急性肾功能衰竭 

分 类 号：R746[医药卫生—神经病学与精神病学]