钝顶螺旋藻藻胆蛋白的抑瘤研究  

Research on anti-tumor effects of phycobiliprotein

作　　者：俞涛 刘祥麟[2] 于晓虹[2] 

机构地区：[1]金华市文荣医院肿瘤外科,浙江金华321013 [2]浙江大学医学院

出　　处：《全科医学临床与教育》2007年第3期181-182,共2页Clinical Education of General Practice

摘　　要：目的研究钝顶螺旋藻藻胆蛋白(phycobiliprotein,PBP)的抑瘤作用。方法给皮下接种H-22肝癌细胞的NIH小鼠,每天分别灌胃PBP15.0mg/kg、7.5mg/kg、3.75mg/kg及腹腔注射PBP15mg/kg,0.9%氯化钠注射液作为对照,共给药7天,第8天处死小鼠,测量肿瘤长短径,算体积,称体重、瘤重和脾重。结果PBP口服中、高剂量对小鼠H-22肝癌有抑制作用,瘤重抑制率分别为71.10%和51.10%,灌胃低剂量及注射高剂量无效。结论PBP对肿瘤有抑制作用。Objective To study the anti - tumor activity of phycobiliprotein（PBP） . Methods H-22 Hepatocar-cinoma cells were transplanted to NIH mouse subcutaneously to establish a tumor - harboring mouse model. Administrated PBP everyday at concentration levels of 15.0 mg/kg, 7.5 mg/kg, 3.75 mg/kg ig. and 15.0 mg/kg ip. Use physiologic saline as a control. After administrated for 7 days, at the 8th day, executed the mice, took the tumor tissue, measured the tumor volume, weighed the tumor, body and spleen. Results Oral administration PBP at high and intermediate concentration levels had significant anti - tumor effects and the tumor weights decreased by 71.1% and 51.1% , respectively. Low concentration level and enterocoelia injection had no significant anti - tumor effects. They did not affect the spleen weight of the tumor - harboring mouse. Conclusions Oral administration of PBP at high and intermediate concentration levels have significant anti - tumor effects.

关 键 词：钝顶螺旋藻藻胆蛋白 H-22肝癌细胞 不平衡氨基酸 抑瘤 

分 类 号：R730.5[医药卫生—肿瘤]