动脉粥样硬化发生中高脂血症与动脉狭窄的作用比较  

Comparing the Effects of Hyperlipoidemia and Arterial Stenosis on Atherosclerosis

作　　者：金海燕[1] 冬毕华[1] 彭旷[1] 孙慧[1] 叶旭[1] 杨永宗[1] 

机构地区：[1]南华大学心血管病研究所,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2006年第12期1020-1024,共5页Chinese Journal of Arteriosclerosis

基　　金：湖南省重点科技项目(01SSY1003)

摘　　要：目的分析比较高脂血症和动脉狭窄在动脉粥样硬化形成中的作用,并探讨其可能的作用机制。方法采用颈总动脉套环术加高脂高胆固醇饲料喂养新西兰白兔,建立兔颈总动脉粥样硬化模型。血浆总胆固醇、甘油三酯和高密度脂蛋白胆固醇的浓度均用酶法测定。用数字剪影动脉造影技术来检测手术效果和动脉狭窄程度。通过病理技术观察血管壁组织形态并进行图象分析。结果喂养9周后,无论是对照组还是高脂组,套环的颈总动脉均发现了大量的泡沫细胞,尤以高脂组更为显著。此时,高脂组兔的主动脉弓部可见脂质条纹,病变面积占主动脉面积的30.8%±6.3%。而对照组兔未见动脉粥样硬化病变。结论结果提示采用颈总动脉套环术,可以使兔颈总动脉在较短时间内在明确预定的部位形成动脉粥样硬化病变。动脉粥样硬化病变的形成与高脂血症和血流动力学的变化密切相关。动脉狭窄可通过血流动力学作用引发粥样硬化病变,该作用可不依赖于高脂血症的存在。动脉狭窄引发的病变在狭窄远心端较近心端严重。Ahn To compare the roles of hyperlipoidemia and arterial stenosis on atherosclerosis, and explore the potential mechanisms. Methods Established atherosclerosis model of rabbit carotid arteries by putting silastic collars around the carotid arteries and raising New Zealand rabbits with a high-fat and high-cholesterol diet. The total cholesterol, triglyceride and high density lipoprotein cholesterol in plasma were measured with kits. The extents of artery stenosis were controlled by digital artefiography. The character of artery morphology was observed with pathology methods. Results After nine weeks, a lot of foam cells were found in the carotid arteries with the collar, whether in the chow diet or high-fat and high -cholesterol diet group, especially in the latter. The rabbit aortic arches of the high-fat and high-cholesterol diet group showed a little fatty streak, but no changes in the chow diet group. Conclusion The results suggested that collars around carotid arteries can induce atherosclerotic lesions in a relatively shorter time and specific area of arteries. The formation of atherosclerotic lesions are closely related with hemodynamic changes and hyperlipidemia. Atherosclerotic lesions can be caused by hemodynamic changes with artery stenosis. Lesions of the area distal to the collar, induced by artery stenosis, were more serious than the area proximal.

关 键 词：病理学与病理生理学 动脉粥样硬化 实验动物 家兔 套环  硅胶 动脉狭窄模型 高脂血症模型 血脂测定 

分 类 号：R363[医药卫生—病理学]