低浓度金属离子体外抗病毒研究  

Study on the antiviral effect of low concentration metal ions on virus in vitro

作　　者：侯欣彤[1] 徐斌斌[2] 刘艳[2] 田晓乐[2] 张益波[2] 孟庆繁[2] 

机构地区：[1]吉林大学畜牧兽医学院,吉林长春130062 [2]吉林大学生命科学学院,吉林长春130012

出　　处：《食品工业科技》2007年第6期110-112,共3页Science and Technology of Food Industry

基　　金：吉林省科技发展基金(20020503-2)。

摘　　要：采用细胞病变效应(CPE)抑制实验观察和分析低浓度Zn2+、Cu2+和Mn2+金属离子对病毒的抑制作用。低浓度Zn2+在体外有较好的抑制单纯疱疹病毒、呼吸道合胞病毒和副流感病毒的致病作用;低浓度Cu2+和Mn2+在体外有较好的抑制副流感的致病作用。研究表明,将金属离子进行复合不但可以提高抑制作用,而且可以降低单一离子的浓度。The cytopathic effect （CPE） inhibitory assay tests were used to investigate the antiviral effect of low concentration metal ions on virus in vitro. Zn^2＋ at low concentration had significant antiviral effect against herpes simplex virus, respiratory syncytial virus and parainfluenza virus： Cu^2＋ and Mn^2＋ at low concentration had significant antiviral effect against parainfluenza virus： the mixture of metal ions had significant antiviral effect against herpes simplex virus, respiratory syncytial virus and parainfluenza virus even if the concentration of each ion was lower. The mixture of Zn^2＋, Cu^2＋ and Mn^2＋ not only reduced the concentration when they were used separately, but also enhanced the antiviral activity.

关 键 词：ZN^2+ CU^2+ MN^2+ 抗病毒活性 复合作用 细胞病变作用 

分 类 号：TS201.26[轻工技术与工程—食品科学]