Ezrin和Moesin在胃癌中的表达及其临床意义  

Expression of Ezrin,Moesin in the Gastric Carcinoma and Its Clinical Significance

作　　者：李莹杰[1] 陶晓峰[2] 贺岩[2] 付红[1] 

机构地区：[1]哈尔滨医科大学附属二院,黑龙江哈尔滨150086 [2]哈尔滨医科大学,黑龙江哈尔滨150086

出　　处：《中国肿瘤》2007年第7期550-552,共3页China Cancer

基　　金：黑龙江省科技厅青年基金资助(Qc05c38);黑龙江省哈医大二院青年基金资助(QN2006-08)

摘　　要：[目的]探讨Ezrin、Moesin在胃癌组织中的表达情况及其与临床病理参数之间的关系。[方法]采用免疫组化法检测50例胃癌组织、25例胃黏膜不典型增生和25例正常胃黏膜中Ezrin、Moesin的表达。[结果]①Ezrin在正常胃黏膜、不典型增生和胃癌中的阳性表达率分别为28.0%、36.0%和86.0%。Moesin在正常胃黏膜、不典型增生和胃癌中的阳性表达率分别为12.0%、24.0%和78.0%。②Ezrin的表达程度与胃癌的临床分期、淋巴结转移有关(P<0.01),与胃癌的分化程度无关(P>0.05)。Moesin的表达程度与胃癌的临床分期、淋巴结转移和分化程度有关(P<0.01)。③Ezrin和Moesin的表达之间呈正相关(P<0.01)。[结论]Ezrin、Moesin在胃癌中的高表达与胃癌的临床分期和淋巴结转移有关,两者的联合检测可能成为预测胃癌转移及预后的重要指标。[Purpose] To explore the expression of Ezfin and Moesin and its correlation to clinico-pathological profile in gastric carcinoma. [Methods] The expression of Ezrin and Moesin in 50 specimens of gastric careinoma, 25 specimens of gastric epithelial dysplasia and 25 specimens of normal gastric tissues were detected by immunohistochemistry. [Results] ①The positive expression rates of Ezrin in normal gastric tissues, gastric epithelial dysplasia and gastric carcinoma were 28.0%, 36.0% and 86.0% and those were 12.0%, 24.0% and 78.0% respetively. ②The expression of Ezrin was correlated to clinical stage, lymph node metastasis（P〈0.01）, but not to differentiation（P〉0.05）, the expression of Moesin was correlated to clinical stage, lymph node metastasis and differentiation（P〈0.01）. ③ The expression of Ezrin was positively cmTelated to that of Moesin in gastric carcinoma （P〈0.01）. [Conclusions] High expression of Ezrin and Moesin is correlated with the clinical stage and lymph node metastasis in gastric carcinoma, combined both detection might be important marker for forecasting metastasis and prognosis in gastric carcinoma examining Ezrin and Moesin.

关 键 词：胃肿瘤 EZRIN MOESIN 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]