2,4,6-三芳基吡啶的微波辐射促进合成  

Synthesis of 2,4,6-Triarylpyridines Under Microwave Irradiation

作　　者：吴萍[1] 蔡习美[2] 颜朝国[2] 

机构地区：[1]扬州职业大学,扬州225009 [2]扬州大学化学化工学院

出　　处：《应用化学》2006年第12期1377-1380,共4页Chinese Journal of Applied Chemistry

基　　金：江苏省自然科学研究指导性计划项目(04KJD150237);扬州市科技指导性计划项目(YZ2004Z021)

摘　　要：在醋酸铵和醋酸体系中,利用微波辐射,研究了氯化N-苯乙酮基吡啶和查尔酮反应,以较高产率得到2,4,6-三芳基吡啶衍生物5a^5g(67%~90%)。研究了氯化N-苯乙酮基吡啶直接与芳醛和取代苯乙酮一锅煮反应,可以得到高产率地2,4,6-三芳基吡啶衍生物5h^5i(77%~84%)。化合物的结构均用1H NMR、IR测试技术进行了表征。Under microwave irradiation, N-phenacylpyridinium chloride 1 reacted with chalcone 2 in the presence of ammonium acetate to afford 2,4,6-triarylpyrididnes 5a -5h in high yields. 2,4,6-Triarylpyridines 5a - 5h can also be prepared from the one-pot reaction of N-phenacylpyridinium chloride with each of aromatic aldehydes 3 and each of substituted acetophenones 4. The products were identified by ^1H NMR and IR spectroscopy.

关 键 词：微波辐射 查尔酮 缩合反应 吡啶 叶立德 

分 类 号：O626.3[理学—有机化学]