肝豆状核变性治疗前后 BAEP 的对比分析  

Contrast analysis of BAEP in patients with hepatolenticular degeneration before and after treatment.

作　　者：许圣弘[1] 蔡永亮[1] 杨任民[1] 

机构地区：[1]安徽中医学院神经病学研究所

出　　处：《临床脑电学杂志》1997年第2期86-88,共3页

摘　　要：６５例肝豆状核变性（ＨＬＤ）患者驱铜治疗前与治疗２个月后，分别进行脑干听觉诱发电位（ＢＡＥＰ）检测，观察其潜伏期（ＰＬ）和峰间期（ＩＰＬ）的变化，并选用３８例健康人为对照组。结果表明，ＨＬＤ患者ＢＡＥＰ的ＰＬ和ＩＰＬ较正常对照组明显延长，主要表现为Ⅲ、Ⅴ波ＰＬ及Ⅲ－Ⅴ、Ⅰ－ⅤＩＰＬ延长，从而提示铜离子在ＨＬＤ患者脑内沉积损害了脑干听觉传导通路。经驱铜治疗后，临床症状有明显的改善，同时ＢＡＥＰ亦显示各波ＰＬ和ＩＰＬ较疗前显著好转。男女患者治疗前的异常率分别为２２％和１９％，治疗后降至９％和７％（Ｐ＜０．０５，Ｐ＜０．０１），ＢＡＥＰ的好转与临床症状的改善一致。The peak latency (PL) and interpeak latency (IPL) of brainstem auditory evoked potential (BAEP) in 65 patients with hepatolenticular degeneration (HLD) are analysed before and after two month treatment with decoppering drugs with 38 healthy subjects served as control.The result showed that PL and IPL were greatly increased,especially in the prolongation of Ⅲ,Ⅴ,Ⅲ-Ⅴ and Ⅰ-Ⅴ,indication that the copper ion depositing in the brain could cause the brainstem auditory conduction passage impaired.After treatment,the clinical symptoms and latencies were greatly improved.The abnormality rate of BAEP in both male and female patients were decreased from 22% and 19% before treatment to 9% and 7% after treatment respectively ( P<0.05 , P<0.01) .It's believed that BAEP as an adjuvant diagnosis might be valuable in the diagnosis of HLD as well as in the judgement of the therapuetic effect.

关 键 词：脑干 听觉诱发电位 肝豆状核变性 治疗 

分 类 号：R742.405[医药卫生—神经病学与精神病学]