L-天冬氨酸六肽-布洛芬的合成  

Synthesis of L-Asp_6-Ibuprofen

作　　者：刘鹏[1] 张昱[1] 郭丽[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2007年第1期49-50,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:20472055)

摘　　要：目的合成可能具有骨靶向性的非甾体抗炎药。方法使用混合酸酐法制备L-天冬氨酸六肽,分别用混合酸酐法和DCC法连接布洛芬,氢化还原得产物。结果制备得到L-天冬氨酸六肽-布洛芬,产物经MS确证。结论所用方法经济,可靠。OBJECTIVE To synthesize the presumable bone - targeting nonsteroidal anti - inflammatory agents. METHODS L - Asp6 was prepared by aspartic acid which was protected. L - AsP6 - Ibuprofen was prepared by mixture anhydrides methods and DCC/ HOBt methods. The benzyl group of the product was deprotected by catalytic hydrogenation. RESULTS Synthesized L - Asp6 - Ihu- profen by liquid phase synthesis was obtained. Chemical structure of product was confirmed by MS. CONCLUSION The result shows that the method of the synthesis of （5） is an efficient and economical method.

关 键 词：骨靶向 天冬氨酸六肽 布洛芬 非甾体抗炎药 

分 类 号：R914[医药卫生—药物化学]