肝病实脾与健脾益气方药对肝细胞蛋白合成功能影响的研究思路  

The Studying Clues of Treating Liver by Nourishing Spleen and Nourishing Spleen and Enriching Qi Herbs on the Effects of Protein Synthesis Function of Hepatocytes

作　　者：宋雅芳[1] 刘友章[1] 吴艳萍[2] 欧志穗[1] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405 [2]河北医科大学,河北石家庄050091

出　　处：《中华中医药学刊》2007年第8期1585-1587,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家科技部973计划资助项目(2005CB523502)

摘　　要：对中医"肝脾相关"理论进行了分析探讨,对肝病实脾、健脾益气方药治疗肝硬化腹水的作用机制提出了新的研究思路。血浆蛋白的合成与分泌在内质网,并是一个耗能的过程,其能量主要来源于线粒体;而线粒体的结构和功能发生改变,也会影响到内质网合成和分泌蛋白的功能。本研究基于健脾益气方药提高血浆蛋白的作用机制可能通过改善线粒体的结构和功能,为内质网合成蛋白提供必要能量的认识,以"肝脾相关"理论为突破口,以"肝病从脾治"为切入点,采用中医学、分子生物学等多学科交叉,拟对健脾益气方药对肝细胞蛋白合成功能的影响进行深入研究,以揭示健脾益气方药提高血浆蛋白的作用机制,丰富"肝脾相关"的理论内涵。Analyzed the TCM theory of ＂liver and spleen correlation＂ , raising the new studying clues on the mechanism of treating liver by nourishing spleen and nourishing spleen and enriching Qi herbs on the treatment of cirrhosis ascites. The synthesis and secretion of plasma protein is in endoplasmic reticulum, which is a consuming energy process , while the energy mainly comes from mitochondria ; While the structure and function of mitochondria changed, also affected the the function of synthesis and secretion of protein of endoplasmic reticulum. This study based on the recognition that the mechanism of nourishing spleen and enriching Qi herbs on promoting plasma protein maybe through improving the structure and function of mitochondria , providing necessary energy for the protein synthesis of endoplasmic reticulmn, from the point of view of the TCM theory of ＂liver and spleen correlation＂ and treating liver by nourishing spleen, through multi - subjects overlap of TCM and molecular biology, making profound study on nourishing spleen and enriching Qi herbs on the effects of protein synthesis function of hepatocytes so as to revealing its mechanism of improving plasma protein and enriching the connotation of the TCM theory of ＂liver and spleen correlation＂.

关 键 词：肝病实脾 健脾益气方药 肝细胞 蛋白合成 

分 类 号：R575.2[医药卫生—消化系统]