先天畸形危险因素的病例对照研究  

Case-control study on the risk factors of congenital malformations

作　　者：王玮[1] 许伟[2] 郑亚军[2] 周宝森[1] 

机构地区：[1]中国医科大学公共卫生学院流行病学教研室,辽宁沈阳110001 [2]沈阳市卫生局基妇处,辽宁沈阳110001

出　　处：《中国儿童保健杂志》2007年第4期403-405,共3页Chinese Journal of Child Health Care

摘　　要：【目的】探讨沈阳市围产儿先天畸形的危险因素,为其干预提供理论依据。【方法】采用以医院为基础的1∶2病例对照研究方法,以统一的调查表及调查方式对142例出生缺陷儿和对照的父母进行了调查,应用Stata 8.0软件对所有调查因素进行回归分析。【结果】先天畸型家族史(OR=3.31)、父亲接触有害化学物质(OR=3.10)、母亲流产史(OR=2.35)、孕期感染病毒(OR=2.34)、孕期不良精神刺激(OR=2.00)、孕期服用激素类药(OR=2.62)与先天畸形的发生呈正相关,而补充复合维生素(OR=0.54)和多食肉蛋豆奶(OR=0.25)与先天畸形的发生呈负相关。【结论】先天畸型是一种多因素的疾病,先天畸型家族史、父亲接触化学物质、母亲有流产史、孕期感染病毒、孕期负性精神刺激、孕期服用激素类药是先天畸形的危险因素,而孕期补充复合维生素和多食肉蛋豆奶为先天畸型的保护因素。[Objective] To investigate the possible risk factors of congenital malformations in Shenyang city. [Methods] A hospitabbased 1 ： 2 matched case-control study was carried out on 142 cases of birth defects and 284 controls. The parents of cases and controls were interviewed with a uniformed questionnaire. Conditional Logistic Regression was used for univalent and multivariate analysis on STATA 8.0. [Results] Family history of positive congenital malformations, paternal exposure to poisonous chemicals, maternal having history of abortion, infecting virus, taking hormone drugs ,bad moral irritate, large consumption of meat, eggs, beans, milk and vitamin during pregnancy were significantly associated with congenital malformations, with odds ratios 3.31, 3.10,2.35,2.34,2.00,2.62,0.54,0.25, respectively. [Conclusion] Family history of positive congenital malformations,paternal exposure to poisonous chemicals, maternal having history of abortion, infecting virus, taking hormone drugs, bad moral irritate are the key risk factors contribution to congenital malformations, while maternal exposure to big meat, eggs, beans, milk and vitamin during pregnancy are protective factors that reducing congenital malformations.

关 键 词：先天畸形 危险因素 病例对照 

分 类 号：R749.94[医药卫生—神经病学与精神病学]