Interaction between N-phosphoryl-α-,β-and γ-amino acids and nucleosides  

作　　者：Li Ming Qiang Shu Xia Cao Yan Chun Guo Xin Cheng Liao Yu Fen Zhao 

机构地区：[1]Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China [2]Key Laboratory for Bioorganic Phosphorus Chemistry of Ministry of Education, Department of Chemistry School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

出　　处：《Chinese Chemical Letters》2007年第8期939-942,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.20572061,20672104);the Chinese Ministry of Education and Zhengzhou University for financial support.

摘　　要：The reactions of four different N-（O,O＇-diisopropyl） phosphoamino acids （DIPP-aa）, such as N-phosphoryl-L-α-alanine （DIPP- L-α-Ala）, N-phosphoryl-D-α-alanine （DIPP-D-α-A1a）, N-phosphoryl-β-alanine （DIPP-β-A1a） and N-phosphoryl-γ-amino butyric acid （DIPP-γ-Aba）, and four nucleosides, adenosine （A）, guanosine （G）, cytidine （C） and uridine （U）, were studied by electrospray ionization tandem mass spectrometry （ESI-MS/MS） and HPLC/ESI-MS. DIPP-L-α-A1a and DIPP-D-α-A1a produced the same phosphorylated nucleosides, dinucleotides and phosphoroligopeptide. However, DIPP-β-A1a and DIPP-γ-Aba gave no relevant products.The reactions of four different N-（O,O＇-diisopropyl） phosphoamino acids （DIPP-aa）, such as N-phosphoryl-L-α-alanine （DIPP- L-α-Ala）, N-phosphoryl-D-α-alanine （DIPP-D-α-A1a）, N-phosphoryl-β-alanine （DIPP-β-A1a） and N-phosphoryl-γ-amino butyric acid （DIPP-γ-Aba）, and four nucleosides, adenosine （A）, guanosine （G）, cytidine （C） and uridine （U）, were studied by electrospray ionization tandem mass spectrometry （ESI-MS/MS） and HPLC/ESI-MS. DIPP-L-α-A1a and DIPP-D-α-A1a produced the same phosphorylated nucleosides, dinucleotides and phosphoroligopeptide. However, DIPP-β-A1a and DIPP-γ-Aba gave no relevant products.

关 键 词：N-phosphoryl amino acids NUCLEOSIDES DINUCLEOTIDES 

分 类 号：O623.736[理学—有机化学]