supported by National Key Research and Development Program of China(Grant Number:2023YFD1700502);Frontiers Science Center for New Organic Matter,Nankai University,(Grant Number:63181206);the Haihe Laboratory of Sustainable Chemical Transformations,China(Grant Number:YYJC202102).
Cyclic dinucleotides(CDNs)play important physiological roles in bacteria,mammals and insects as a novel class of signaling molecules.However,the application of CDNs in agricultural pest control has not been reported y...
funded by Research Foundation of China Association Against Epilepsy(CU-2024-042);Medical Scientifc Research Foundation of Guangdong Province(A2024536);the National Natural Science Foundation of China(Grant No.82071548,Grant No.82301639 and Grant No.82201609);Guangzhou Medical University Student Innovation Ability Promoting Program(Grant No.2022A045 and Grant No.02-408-240603131135).
Background SCN1A is the most well-recognized and commonly mutated gene related to epilepsy.This study analyzed the characteristic spatial and frequency distributions of SCN1A mutations,aiming to provide important insi...
supported by the National Key R&D Program of China(nos.2019YFA0904200 and 2018YFA0507600);the Tsinghua University Spring Breeze Fund(no.2020Z99CFY042);the National Natural Science Foundation of China(nos.92053108 and 31961143004);NCC Fund(no.NCC2020FH04).
Stimulator of interferon genes,namely STING,an adaptor protein located in the endoplasmic reticulum,has been recognized as a shining target for cancer and infection research.However,STING agonists cyclic dinucleotides...
the National Natural Science Foundation of China(No.81770754);the Beiing Natural Science Foundation(No.7172081)at Beijing Chaoyang Hospital,Capital Medical University,through funding provided to YNN.
The inhibition of 5-a reductase type 2(SRD5A2)by finasteride is commonly used for the management of urinary obstruction resulting from benign prostatic enlargement(BPE).Certain BPE patients showing no SRD5A2 protein e...
the National Key Research and Development Program of China(2017YFD0200500);the National Natural Science Foundation of China(21740002,21837001)。
Cyclic dinucleotides(CDNs) are known to activate stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infecti...
National Natural Science Foundation of China(Grant No.U1604285,21572013)
C-di-GMP is one kind of second messengers which plays an important role not only in the regulation of various bacterial physiological activities but also in the activation of innate immune response to induce typeⅠint...
National Natural Science Foundation of China (Grant No. 20832008 and 21002004)
Three dinucleotides containing L-isonucleosides at 5'-end were synthesized by an elegant phosphoramidite one-pot method. Their binding modes with HIV integrase were simulated and their anti-HIV activities in pseudoty...
Deformability of DNA is important for its superhelical folding in the nucleosome and has long been thought to be facilitated by periodic occurrences of certain dinucleotides along the sequences, with the period close ...
the National Natural Science Foundation of China(Nos.20572061,20672104);the Chinese Ministry of Education and Zhengzhou University for financial support.
The reactions of four different N-(O,O'-diisopropyl) phosphoamino acids (DIPP-aa), such as N-phosphoryl-L-α-alanine (DIPP- L-α-Ala), N-phosphoryl-D-α-alanine (DIPP-D-α-A1a), N-phosphoryl-β-alanine (DIPP...
The work was supported partly by the National High-Tech Research and Development Program(863 program,No.2003AA231050);the National Natural Science Foundation of China(No.10371126).
DNA composition dynamics across genomes of diverse taxonomy is a major subject of genome analyses. DNA composition changes are characteristics of both replication and repair machineries. We investigated 3,611,007 sing...