云南高校图书馆联盟文献共享服务平台- DINUCLEOTIDES

DINUCLEOTIDES: 作品数：11被引量：7H指数：2; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：王萌张礼和邢磊杨振军关注更多>>; 相关机构：北京大学更多>>; 相关期刊：《Acta Epileptologica》《Science China Chemistry》《Journal of Biomedical Science and Engineering》《Genomics, Proteomics & Bioinformatics》更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划更多>>

Design,synthesis and bioactivity of cyclic dinucleotides against Lepidoptera insects: 《Advanced Agrochem》2024年第4期337-343,共7页Zhiqiang Xie Sijing An Dejun Ma Zhen Xi; supported by National Key Research and Development Program of China(Grant Number:2023YFD1700502);Frontiers Science Center for New Organic Matter,Nankai University,(Grant Number:63181206);the Haihe Laboratory of Sustainable Chemical Transformations,China(Grant Number:YYJC202102).; Cyclic dinucleotides(CDNs)play important physiological roles in bacteria,mammals and insects as a novel class of signaling molecules.However,the application of CDNs in agricultural pest control has not been reported y...; 关键词：Antifeedant activity Insecticidal activity Cyclic dinucleotides LEPIDOPTERA

Characteristic spatial and frequency distribution of mutations in SCN1A: 《Acta Epileptologica》2024年第4期327-335,共9页Mengwen Zhang Jing Guo Bin Li Kang Liu Jiayuan Zhao Jiayuan Zhang Xuqing Lin Bin Tang Jie Wang Weiping Liao Na He; funded by Research Foundation of China Association Against Epilepsy(CU-2024-042);Medical Scientifc Research Foundation of Guangdong Province(A2024536);the National Natural Science Foundation of China(Grant No.82071548,Grant No.82301639 and Grant No.82201609);Guangzhou Medical University Student Innovation Ability Promoting Program(Grant No.2022A045 and Grant No.02-408-240603131135).; Background SCN1A is the most well-recognized and commonly mutated gene related to epilepsy.This study analyzed the characteristic spatial and frequency distributions of SCN1A mutations,aiming to provide important insi...; 关键词：Epilepsy SCN1A CpG dinucleotides Mutation hotspot Spatial and frequency distribution

CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination被引量：2: 《CCS Chemistry》2023年第4期885-901,共17页Jun-Jun Wu Fang-Yuan Chen Bei-Bei Han Hong-Qing Zhang Lang Zhao Zhe-Rui Zhang Juan-Juan Li Bo-Dou Zhang Ya-Nan Zhang Yu-Xin Yue Hong-Guo Hu Wen-Hao Li Bo Zhang Yong-Xiang Chen Dong-Sheng Guo Yan-Mei Li; supported by the National Key R&D Program of China(nos.2019YFA0904200 and 2018YFA0507600);the Tsinghua University Spring Breeze Fund(no.2020Z99CFY042);the National Natural Science Foundation of China(nos.92053108 and 31961143004);NCC Fund(no.NCC2020FH04).; Stimulator of interferon genes,namely STING,an adaptor protein located in the endoplasmic reticulum,has been recognized as a shining target for cancer and infection research.However,STING agonists cyclic dinucleotides...; 关键词：STING agonist cyclic dinucleotides CALIXARENE supramolecular delivery cancer immunotherapy SARS-CoV-2 vaccine adjuvant

Methylated CpG dinucleotides in the 5 -a reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients被引量：2: 《Asian Journal of Andrology》2021年第3期266-272,共7页Zhe-Min Lin Dong-Dong Fan Song Jin Zhan-Liang Liu Yi-Nong Niu; the National Natural Science Foundation of China(No.81770754);the Beiing Natural Science Foundation(No.7172081)at Beijing Chaoyang Hospital,Capital Medical University,through funding provided to YNN.; The inhibition of 5-a reductase type 2(SRD5A2)by finasteride is commonly used for the management of urinary obstruction resulting from benign prostatic enlargement(BPE).Certain BPE patients showing no SRD5A2 protein e...; 关键词：5-a reductase benign prostatic enlargement CpG island methylated CpG dinucleotides METHYLATION

Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants被引量：2: 《Science China Chemistry》2020年第4期534-545,共12页Zheng-Hua Wang Can-Can Zhao Qiang-Zhe Zhang Chuan-Lin Wang Hang Zhang De-Jun Ma Da-Wei Wang Xin Wen Lu-Yuan Li Zhen Xi; the National Key Research and Development Program of China(2017YFD0200500);the National Natural Science Foundation of China(21740002,21837001)。; Cyclic dinucleotides(CDNs) are known to activate stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infecti...; 关键词：CYCLIC dinucleotides(CDNs) STIMULATOR of INTERFERON genes(STING) pyrimidine CDNs interferonβ ecto-nucleotide pyrophosphatase/phosphodiesterase 1(ENPP1)

Synthesis of c-di-GMP analogs modified by ganciclovir and biological activity to induce type Ⅰ interferon: 《Journal of Chinese Pharmaceutical Sciences》2019年第12期825-834,共10页Hong Dai Xiaotong Yu Zhu Guan Lihe Zhang Zhenjun Yang; National Natural Science Foundation of China(Grant No.U1604285,21572013); C-di-GMP is one kind of second messengers which plays an important role not only in the regulation of various bacterial physiological activities but also in the activation of innate immune response to induce typeⅠint...; 关键词：Cyclic dinucleotides c-di-GMP analogs GANCICLOVIR TypeⅠinterferon

Synthesis and the anti-HIV activity of novel dinucleotides containing L-isonucleosides: 《Journal of Chinese Pharmaceutical Sciences》2013年第4期314-318,共5页王萌邢磊陆世芳关注杨振军张礼和; National Natural Science Foundation of China (Grant No. 20832008 and 21002004); Three dinucleotides containing L-isonucleosides at 5＇-end were synthesized by an elegant phosphoramidite one-pot method. Their binding modes with HIV integrase were simulated and their anti-HIV activities in pseudoty...; 关键词：HIV integrase DINUCLEOTIDES SYNTHESIS ANTI-HIV Binding modes

Statistical analysis of conformational properties of periodic dinucleotide steps in nucleosomes: 《Journal of Biomedical Science and Engineering》2010年第4期331-339,共9页Xi Yang Hong Ya; Deformability of DNA is important for its superhelical folding in the nucleosome and has long been thought to be facilitated by periodic occurrences of certain dinucleotides along the sequences, with the period close ...; 关键词：DEFORMABILITY of DNA NUCLEOSOME DINUCLEOTIDES 10.5-Base Periodicity Deformation Preferences Flexibility DNA Bending

Interaction between N-phosphoryl-α-,β-and γ-amino acids and nucleosides: 《Chinese Chemical Letters》2007年第8期939-942,共4页Li Ming Qiang Shu Xia Cao Yan Chun Guo Xin Cheng Liao Yu Fen Zhao; the National Natural Science Foundation of China(Nos.20572061,20672104);the Chinese Ministry of Education and Zhengzhou University for financial support.; The reactions of four different N-（O,O＇-diisopropyl） phosphoamino acids （DIPP-aa）, such as N-phosphoryl-L-α-alanine （DIPP- L-α-Ala）, N-phosphoryl-D-α-alanine （DIPP-D-α-A1a）, N-phosphoryl-β-alanine （DIPP...; 关键词：N-phosphoryl amino acids NUCLEOSIDES DINUCLEOTIDES

NEIGHBORING-NUCLEOTIDE EFFECTS ON THE MUTATION PATTERNS OF THE RICE GENOME被引量：1: 《Genomics, Proteomics & Bioinformatics》2005年第3期158-168,共11页Hui Zhao Qi-Zhai Li Chang-Qing Zeng Huan-Ming Yang Jun Yu; The work was supported partly by the National High-Tech Research and Development Program(863 program,No.2003AA231050);the National Natural Science Foundation of China(No.10371126).; DNA composition dynamics across genomes of diverse taxonomy is a major subject of genome analyses. DNA composition changes are characteristics of both replication and repair machineries. We investigated 3,611,007 sing...; 关键词：CpG dinucleotides METHYLATION SNP transcription-coupled repair

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