Synthesis and the anti-HIV activity of novel dinucleotides containing L-isonucleosides  

L-异核苷掺入的二核苷酸的合成与抗HIV活性研究(英文)

作　　者：王萌[1,2] 邢磊[1,2] 陆世芳[1,2] 关注[1,2] 杨振军[1,2] 张礼和[1,2] 

机构地区：[1]北京大学医学部天然药物及仿生药物国家重点实验室 [2]药学院药物化学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2013年第4期314-318,共5页中国药学（英文版）

基　　金：National Natural Science Foundation of China (Grant No. 20832008 and 21002004)

摘　　要：Three dinucleotides containing L-isonucleosides at 5＇-end were synthesized by an elegant phosphoramidite one-pot method. Their binding modes with HIV integrase were simulated and their anti-HIV activities in pseudotyped virus system were examined.本论文利用亚磷酰胺一釜法合成了三个5'-端L-构型异核苷掺入的非天然二核苷酸, 对它们与HIV整合酶的结合模式进行了模拟, 并对它们在假病毒体系中的抗HIV活性进行了评价。

关 键 词：HIV integrase DINUCLEOTIDES SYNTHESIS ANTI-HIV Binding modes 

分 类 号：R914[医药卫生—药物化学]