Synthesis of a 1,2,7,8-Tetraoxa-spiro[5.5]undecane  

作　　者：张琦 李云 伍贻康 

机构地区：[1]State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2007年第9期1304-1308,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation 0f China （Nos. 20025207, 20272071, 20372075, 20321202, 20672129, and 20621062）, and the Chinese Academy of Sciences （Nos. NKGCX2-SW-209 and KJCX2.YW.H08）.

摘　　要：Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy linkage. The hydroperoxyl groups were then bonded at the OH ends via Hg（II）-induced electrophilic additions to the C-C double bonds, giving a novel sprio structure with one peroxy bond in each of the two six-membered rings. The ester functionalities in the side chains also make it possible to conduct further structural modifications.Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy linkage. The hydroperoxyl groups were then bonded at the OH ends via Hg（II）-induced electrophilic additions to the C-C double bonds, giving a novel sprio structure with one peroxy bond in each of the two six-membered rings. The ester functionalities in the side chains also make it possible to conduct further structural modifications.

关 键 词：PEROXIDE ANTIMALARIAL ARTEMISININ hydrogen peroxide spiro compound 

分 类 号：R962[医药卫生—药理学]