牛磺酸在视网膜缺血病变中抗氧化作用的实验研究  

EXPERIMENTAL RESEARCH IN EFFECT OF TAURINE AND ITS ANTIOXIDATIVE DAMAGE AFTER RETINAL ISCHEMIA REPERFUSION

作　　者：于亚男[1] 李晓芳[2] 毕力夫[3] 

机构地区：[1]中国人民武装警察部队内蒙古总队医院眼科,内蒙古呼和浩特010031 [2]内蒙古医学院附属医院眼科 [3]内蒙古医学院

出　　处：《内蒙古医学院学报》2007年第4期250-252,共3页Acta Academiae Medicinae Neimongol

摘　　要：目的:探讨牛磺酸对大鼠视网膜缺血再灌注后视网膜脂质过氧化产物丙二酰二醛(MDA)、超氧化物歧化酶(SOD)的影响。方法:以升高眼压方式造成视网膜缺血,做成高眼压模型,测定视网膜匀浆中MDA含量与SOD活性的变化,并进行统计学分析。结果:MDA含量测定各组无显著性差异(P>0.05);牛磺酸组及维生素E组SOD活性升高。结论:牛磺酸对视网膜缺血再灌注损伤有一定的保护作用。Objective： To explore the effect of taurine on MDA and SOD. Methods： Retinal ischemia model was made by elevating intraocular pressure. The amount of the malondialdehyde（MDA） and the activity of superoxide dismutase （SOD） in the retina were determined and analyzed statistically. Results： Every group had no difference while testing MDA （ P 〉 0. 05 ）. The activity of SOD have been raised in taurine - supplemented group and vitamin E group （P 〈 0. 05 ）. Conclusion：Taurine has protective effect on rat retina ischemia -reperfusion.

关 键 词：牛磺酸 视网膜 丙二酰二醛 超氧化物歧化酶 

分 类 号：R774.1[医药卫生—眼科]