额叶癫痫手术长期效果及其相关因素研究  

LONG-TERM OUTCOME AND ITS RELATED FACOTORS OF FRONTAL LOBE EPILEPSY SURGERY

作　　者：万衡[1] 刘力克[1] 胡柠杉[1] 马骁[1] 雷町[2] 周泽永[2] 邝璞[2] 

机构地区：[1]四川大学华西第四医院,成都610041 [2]四川大学华西医院

出　　处：《现代预防医学》2007年第19期3680-3681,3684,共3页Modern Preventive Medicine

摘　　要：[目的]总结分析额叶癫痫手术长期效果,并评估影响长期预后的术前相关因素。[方法]对97例额叶癫痫手术患者进行长期追踪随访,回顾性研究影响患者预后的因素。[结果]22%术后无癫痫再发,9%术后仅有先兆发作,18%在随访期间偶有痫性发作。首次癫痫发作年龄小于12岁、癫痫病程小于6年、发作时无先兆、发作频率大于10次/月、MRI上单侧额叶病灶及开颅手术中皮质脑电图呈明显β样放电预示ILAE I类结果。[结论]首次癫痫发作年龄、癫痫病程、发作有无先兆、发作频率、磁共振结果、术中皮质脑电图放电模式预示手术长期效果。[Objective]To analyze the long-term results of frontal lobe epilepsy surgery,and to evaluate the preoperative factors predicting a good postoperative outcome in long-term follow up.[Methods]97 adult patients operated on for frontal lobe epilepsy were longitudinal followed up,the preoperative factors which could predict the postoperative outcomes were evaluated with Logistic regression.[Results]22% of the patients became seizure-free,9% had only postoperative auras,and 18% had rare seizures.Onset of epilepsy before the age of 12,the time of the disease being less than 6 years、absence of aura、seizure frequency being more than 10 times per month、unifrontal structural lesions on qualitative MR imaging、and ECoG detecting predominant β type discharge predicted ILAE I outcome.[Conclusion]Age of onset of epilepsy,the course of the disease、absence of aura or not,seizure frequency,MR imaging,and ECoG detecting discharge are the factors associated with good postoperative outcome.

关 键 词：额叶癫痫 EEG MRI 手术 

分 类 号：R742.1[医药卫生—神经病学与精神病学]