SCN5A基因突变与青壮年猝死综合征  

The relationship between SCN5A gene mutation and the occurrence of sudden unexplained nocturnal death syndrome

作　　者：周峰[1] 成建定[1] 

机构地区：[1]中山大学中山医学院法医病理学教研室,广东广州510080

出　　处：《国际内科学杂志》2007年第9期556-558,共3页International Journal of Internal Medicine

基　　金：国家自然科学基金(30500581);广东省自然科学基金(05001685)

摘　　要：青壮年猝死综合征(SUNDS)的病因迄今不明。随着分子遗传学和心脏离子通道研究的深入,SCN5A基因突变已被确定为Brugada综合征、3型长QT间期综合征的最重要病因。本文综述文献,结合项目组研究,介绍SCN5A基因突变与SUNDS发生的相关性。The etiology of sudden unexplained nocturnal death syndrome （SUNDS） is so far unknown. With the deep research on molecular genetics and cardiac ion channel, The SCNSA mutation was confirmed to be the most important cause of Brugada syndrome and Type 3 Long QT interval syndrome. According to our epidemiologic data and literatures, the relationship between SCNSA gene mutation and the occurrence of SUNDS were illuminated in the text.

关 键 词：青壮年猝死综合征 SCN5A 基因突变 

分 类 号：R541[医药卫生—心血管疾病]