复杂疾病病因研究中基因间交互作用分析：基于基因型传递不平衡的多因子降维法  

Identification of gene-gene interactions related to the etiology of complex disease:a multifactor dimenstonality reduction-genotype pedigree disequilibrium test

作　　者：李娜[1] 唐迅[1] 陈大方[1] 胡永华[1] 

机构地区：[1]北京大学医学部公共卫生学院流行病与卫生统计学系,100083

出　　处：《中华流行病学杂志》2007年第10期1036-1040,共5页Chinese Journal of Epidemiology

基　　金：国家"十五"科技攻关课题资助项目(2001BA703B02)

摘　　要：【导读】介绍复杂疾病病因研究中分析基因-基因交互作用的一种新方法:基于基因型传递不平衡的多因子降维法(MDR-PDT)。文中简述MDR-PDT的基本原理、步骤及特点,并结合研究实例说明其应用过程。MDR-PDT是原始MDR的扩展,可用于多种结构类型的核心家系资料分析基因-基因交互作用。结论MDR-PDT具有非参数、无需遗传模式的特点,并能充分利用家系中多个家庭成员的信息,在复杂疾病病因研究中分析基因-基因交互作用具有良好的效能。To introduce the application of a multifactor dimensionality reduction-genotype pedigree disequilibrium test （MDR-PDT） for detecting gene-gene interactions in the etiology of complex disease. A brief overview on the basic theory, implementing steps and features of MDR-PDT were described, and a practical research case was demonstrated to application of MDR-PDT in nuclear family studies. The MDR- PDT approach was the extension or development of conventional MDR method which could be used for detecting gene-gene interactions in families of diverse structure. Conclusion MDR-PDT was a new nonparametric and model-free method which might use additional family members in the nuclear families and had a good power to identify gene-gene interactions.

关 键 词：多因子降维法 核心家系 复杂疾病 基因-基因交互作用 

分 类 号：R363.1[医药卫生—病理学]