Roles of NF-κB in central nervous system damage and repair  

NF-κB在中枢神经系统损伤和修复中的作用

作　　者：杨丽[1] 陶陆阳[1] 陈溪萍[1] 

机构地区：[1]苏州大学医学院法医学教研室苏州大学衰老与神经疾病实验室,苏州215123

出　　处：《Neuroscience Bulletin》2007年第5期307-313,共7页神经科学通报（英文版）

基　　金：National Natural Science Foundation of China （No. 30571909）; the Youth Teacher＇s Research Foundation of Jiangsu Province, China （No. BU 134701 ）; the Medical Development Foundation of Soochow University （No. EE134615）.

摘　　要：NF-κB family is a kind of nuclear factors in B lymphocyte that can bind to the immunoglobulin κ-chain enhancer and enhance transcriptional activity. NF-κB/Rel proteins, as a dimeric transcription factor, control the expression of genes that regulate a broad range of biological processes through canonical and non-canonical pathways. In the central nervous system, NF-κB controls inflammatory reactions and the apoptotic cell death following nerve injury. It also contributes to the infarction and cell death in stroke models and patients. However, NF-κB is essential for neurosurvival as well. NF-κB activation is a part of recovery process that may protect neurons against oxidative-stresses or brain ischemia-induced apoptosis and neurodegeneration. Inhibition of NF-κB may reduce its neuroprotection activity. Hence the dual opposite effects of NF-κB on cells. The ultimate survival or death of neurons depends on which, where and when the NF-κB factors are activated.细胞核因子-κB(nuclear factor kappa B,NF-κB)家族是B淋巴细胞核因子,它能够与免疫球蛋白κ链增强子结合并增加各种基因的表达活性。NF-κB通过典型和非典型途径的激活来控制和调节各种生理病理过程。在中枢神经系统,NF-κB调控炎症反应、神经损伤后的神经细胞凋亡等,它可以促进中风等缺血性脑损伤的脑梗死面积和神经元死亡,同时又对神经元的存活有重要影响。NF-κB激活是神经康复的重要组成部分,它能够保护神经元免于由氧化应激和脑缺血诱导的神经元凋亡和变性,阻滞NF-κB活性将影响它的神经保护机制。NF-κB这种对神经元存活和死亡的双重效应取决于NF-κB激活的亚单位类型、激活所处的损伤位置以及损伤后修复的时程。

关 键 词：NF-ΚB central nervous system INJURY REPAIR 

分 类 号：R741[医药卫生—神经病学与精神病学]