大鼠第一腮弓肾被膜下种植的成牙能力研究  

Study on Odontogenesis Ability of Rat First Branchial Arch Implanted in Renal Capsule

作　　者：邓蔓菁[1] 陈小红[1] 刘鲁川[1] 安建平[1] 匡桂英[1] 

机构地区：[1]第三军医大学野战外科研究所大坪医院口腔科,重庆400042

出　　处：《口腔医学研究》2007年第5期502-504,共3页Journal of Oral Science Research

基　　金：第三军医大学科技创新工程(2004);重庆市自然科学基金资助(编号:2005bb5307)

摘　　要：目的:观察E12.5d大鼠第一腮弓肾被膜下的成牙能力。方法:切取E12.5d大鼠第一腮弓(下颌突),种植于肾被膜下,4周后收获种植的组织块,组织学观察种植的第一腮弓的发育情况。结果:种植4周,第一腮弓在肾被膜下继续发育,形成牙齿样结构,包含牙釉质、牙本质、牙髓、成牙本质细胞、上皮根鞘样结构及骨样组织。形成的组织结构与正常发育的牙齿形态结构相似。结论:E12.5d大鼠第一腮弓在肾被膜下可以模拟体内牙齿的发育过程,继续发育形成牙齿样结构。Objective：To evaluate the dentification ability of E12.5 rat first branchial arch.Methods：The first branchial arch（mandibular process）of E12.5 SD rat was minced and implanted in renal capsule of adult SD rat.Following 4 weeks growth in renal capsule,the specimen was harvested and evaluated by histological assay.Results：4 weeks after implantation,the first branchial arch（mandibular process）developed continuously and tooth-like mineralized structure including enamel-like tissue and dentin-pulp complex was observed.Also Hertwig＇s epithelial root sheath and bone was observed.These forming structures were similar to that of normal developing tooth.Conclusion：Mandibular process of first branchial arch in E12.5 can develop in renal capsule and this process closely parallels to that of natural odontogenesis in vivo.

关 键 词：第一腮弓 种植 牙齿发育 

分 类 号：R78[医药卫生—口腔医学]