Synthesis and antitumor activity of derivatives of 23-hydroxybetulinic acid  

作　　者：Jin Pei Zhou Dan Li Xiao Ming Wu Wen Cai Ye Lu Yong Zhang 

机构地区：[1]Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China [2]Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China [3]National Drug Screening Center, China Pharmaceutical University, Nanjing 210038, China

出　　处：《Chinese Chemical Letters》2007年第10期1195-1198,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of the People's Republic of China(No.30472083).

摘　　要：A series of natural product 23-hydroxybetulinic acid derivatives were prepared. In the preparation of mono-O-benzoyl ester derivative, it was observed that benzoyl group migrated from 3-0- to 23-O-position during the detritylation.A series of natural product 23-hydroxybetulinic acid derivatives were prepared. In the preparation of mono-O-benzoyl ester derivative, it was observed that benzoyl group migrated from 3-0- to 23-O-position during the detritylation.

关 键 词：23-Hydroxybetulinic acid TRITERPENOID ANTITUMOR SYNTHESIS 

分 类 号：TQ46[化学工程—制药化工]