起效时间与有效时间对药物依赖潜能的影响  

Influence of onset and duration of action on addiction potential of abused drugs

作　　者：俞纲[1] 宫泽辉[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》2007年第10期1261-1264,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)资助项目(No2003CB515400)

摘　　要：药动学因素可以影响药物的依赖潜能。成瘾性药物起效越快,依赖潜能越大,其机制可能包括起效时间对药物欣快效应、强化效应以及精神运动效应的影响。延长药物的有效时间虽然可使动物自身给药反应率下降,但对药物依赖潜能的高低可能没有明显的影响。理解药动学因素与药物依赖潜能的关系将有助于临床合理用药以及新型药物的研发。The addiction potential of abused drugs can be different although their pharmacodynamics characteristics are quite similar. In this article, the influence of pharmacokinetics characteristics of a drug on its addiction potential was discussed. A more rapid rate of onset had been shown to result in greater propensity to addiction. Although prolonging the duration of action could reduce the responding rate in animal self-administration experiments, it might not influence ihe strength of a drug. Understanding the relationship between the pharmacokinetics characteristics and addiction potential may contribute to the rational use and development of these kinds of drugs.

关 键 词：起效时间 有效时间 药物成瘾 

分 类 号：R-05[医药卫生] R969.1