HOXA11在子宫内膜单纯性增生和内膜癌中表达增加  

Expression of HOXA 11 in human endometrial hyperplasia and adenocarcinoma

作　　者：胡营营[1] 唐颖[1] 王莉芬[1] 吕丽[1] 王乃玉[1] 冯晓海[1] 唐远馨 

机构地区：[1]大连医科大学附属第二医院病理科,辽宁大连116027 [2]广汉市人民医院病理科,四川广汉618300

出　　处：《基础医学与临床》2007年第10期1123-1126,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30471814)

摘　　要：目的探讨HOXA11基因在子宫内膜单纯性增生和子宫内膜癌中表达的意义,以及与雌激素受体(estrogen receptor,ER)、孕激素受体(progestogene receptor,PR)表达的关系。方法用免疫组化法检测增生期子宫内膜、子宫内膜单纯性增生及子宫内膜癌组织中HOXA11、ER及PR蛋白的表达。结果在子宫内膜单纯性增生和内膜样腺癌中,HOXA11的表达明显高于增生期子宫内膜(P<0.05),而ER、PR的表达明显低于增生期内膜(P<0.05)。结论HOXA11的过度表达可能参与了子宫内膜异常增生或癌变的过程;这种效应可能与ER、PR表达下降相关。Objective To examine HOXA11, ER and PR expression in human endometrial hyperplasia and adenocarcinoma. Methods The immunohistochemistry was applied to analyze the level of HOXA11 .ER and PR expression in the proliferative endometria, simple hyperplasia and endometrial adenocarcinoma. Results The expression level of HOXA11 in the endometrial hyperplasia and adenocarcinoma was significantly higher than that of proliferative endometrium （P 〈 0.05 ）. Compared with proliferative endometrium, the expression of ER and PR in the endometrial hyperplasia and adenocarcinoma was decreased （ P 〈 0. 05 ）. Conclusion Overexpression of HOXA11, which is associated with the decreased expression of ER and PR, and loss of down - regulated HOXA11 by progestogen, may facilitate abnormal proliferation or adenocarcinoma of the endometrium.

关 键 词：HOXA11 子宫内膜单纯性增生 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤] R711.74[医药卫生—临床医学]