大豆肽对高脂血症大鼠的降脂作用  

EFFECTS OF SOYBEAN PEPTIDES ON BLOOD LIPIDS IN HYPERLIPIDEMIA RATS

作　　者：包乐媛[1] 张业尼[1] 钱磊[1] 王建玲[1] 邹菁[1] 路福平[1] 杜连祥[1] 

机构地区：[1]天津市工业微生物重点实验室天津科技大学生物工程学院,天津300457

出　　处：《大豆科学》2007年第5期752-756,共5页Soybean Science

基　　金：天津科技大学自然科学资金资助(20060206)

摘　　要：研究大豆肽对高脂血症大鼠的降血脂、抗氧化作用以及对血液流变学指标的影响。采用高脂饲料喂养SD大鼠造成高脂血症模型,然后随机分组:正常组、高脂模型组、血脂康组(100 mg kg^(-1)d^(-1))、大豆肽灌胃组(400 mg kg^(-1)d^(-1))、大豆肽灌胃组(800 mg kg^(-1)d^(-1))、大豆肤腹腔注射组(100 mg kg^(-1)d^(-1))、大豆肽腹腔注射组(400 mg kg^(-1)d^(-1)),正常组给予普通饲料喂养,其余组给予高脂饲料。持续给药大豆肽30 d,期间每两周眼静脉取血一次,分离血清,检测TC、TG和HDL-C指标;实验结束当天腹主动脉取血,分离血清,检测SOD、MDA和NO指标。结果显示大豆肽能显著降低高脂血症大鼠的TC、TG和LDL-C,但对HDL-C没有显著影响;大豆肽给药组的SOD指标明显高于模型对照组,而MDA和NO指标则显著降低。表明大豆肽液对高脂血症大鼠具有一定的降脂作用,能降低血浆黏度,同时提高机体抗氧化能力。To observe the effects of soybean peptides on regulation of liquid metabolism, hemorheological indexes,antioxidation in rats with hyperlipidemia. Sixty-three SD rats were randomly divided into seven groups as normal control group, model control group, Xuezhikang （100 mg kg^-1 d^-1,i.p.） group,soybean peptide （400 mg kg^-1 d^-1,i.g.） group,soybean peptide （800 mg kg^-1 d^-1 ,i. g. ） group,soybean peptide （100 mg kg^-1 d^-1 ,i. p. ） group and soybean peptide （400 mg kg^-1 d^-1, i. p. ） group. All rats were fed with high-lipid forage except normal control group. Soybean peptides were administered continually for 30 days and blood was collected to detect TC,TG and HDL-C in serum once every two weeks and the levels of serum SOD,MDA and NO were assayed at the last day. Results showed that soybean peptides could significantly decrease TC,TG and LDL-C levels in experimental hyperlipidemia rats （P（0.05）,but it had no significant effect on the level of HDL-C （P〉0.05）. The activity of SOD in rats of soybean peptides administered groups were much higher than those of model control group （P〈0.05）. Meanwhile,the MDA and NO levels in rats of soybean peptides administered groups were much lower than those of model control group （P〈0.05）. The results suggested that the Soybean Peptides can regulate the liquid metabolism,improve hemorheological indexes,increase the activity of scavenging free radicals in rats with hyperlipidemia.

关 键 词：大豆肽 血脂 抗氧化 血液流变学 

分 类 号：R589.2[医药卫生—内分泌]