青少年慢性粒细胞白血病急变临床分析  

Analysis on Clinical Manifestations of Adolescent with Chronic Granulocytic Leukemia in Acute Phase

作　　者：易彦[1] 肖乐[1] 赵云[1] 陈孟君[1] 阳盛[1] 

机构地区：[1]中南大学湘雅二医院血液科,湖南长沙410011

出　　处：《现代生物医学进展》2007年第11期1695-1697,共3页Progress in Modern Biomedicine

基　　金：湖南省自然科学基金:血小板中非肌性肌球蛋白重链ⅡA互作蛋白研究(06CD034)

摘　　要：目的:分析青少年慢性粒细胞白血病(CGL)急变患者临床表现及实验检查特点,以提高对青少年CGL急变临床特点的认识。方法:将CGL急变患者按年龄分组,将青少年组和中老年组患者的急变时间、确诊时和急变时的脾脏大小、白细胞和血小板数目、急变时骨髓幼稚细胞的比例,以及患者的总生存时间、急变后生存时间进行对比分析。结果:青少年组和中老年组的脾脏大小、确诊时血小板数目、急变时的白细胞数目、急变时间、以及总生存时间无显著性差异;青少年组确诊时的白细胞数目较中老年组高,青少年组的急变后生存时间较长。结论:青少年CGL患者的临床表现及实验室检查结果具有CGL的普遍特征,但其确诊时白细胞数目较高,急变后生存时间较长。Objective： To understand futher on clinical and laboratory manifestations of adolescent patients with chronic granulocytic leukemia （CGL） in acute phase. Methods： Based on their ages, Patients with CGL in acute phase were distributed into adolescent group and middle-aged and aged group. Then the clinical manifestations, including spleen size, white cell counts, platelet counts, total survival time （TST）, survival time after acute transformation, etc. of the two groups were compared with each other. Results： There were no significant differences in spleen size, white blood cell and platelet counts and TST of the two groups; while adolescent group had higher white blood cell counts and longer survival time after acute transformation. Conclusion： Adolescent patients with CGL in acute phase have the general clinical manifestations of CGL, with higher white blood cell counts when they were diagnosed and longer survival period after acute transformation.

关 键 词：慢性粒细胞白血病 急变期 青少年 临床特点 

分 类 号：R733.72[医药卫生—肿瘤]