β-胡萝卜素和叶绿酸对DMBA诱发大鼠乳腺癌的影响  

EFFECTS OF β CAROTENE AND CHLOROPHYLLIN ONINCIDENCE OF MAMMARY TUMOR INDUCED BY DIMETHYLBEN(A) ANTHRACENE IN RAT

作　　者：郑一凡[1] 朱心强[1] 黄幸纾[1] 

机构地区：[1]浙江医科大学毒理研究室

出　　处：《癌变．畸变．突变》1997年第2期99-102,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：５０天龄雌性ＳＤ大鼠随机分为４组，每组２５只。Ⅰ组每只大鼠一次灌胃给予ＤＭＢＡ１０ｍｇ；Ⅱ组给ＤＭＢＡ前饮水中加ＣＨＬ１．５ｍｍｏｌ／Ｌ，持续１ｗｋ；Ⅲ组给ＤＭＢＡ后饲料中加ＢＣ９０ｍｇ／ｋｇ饲料，持续到实验结束；Ⅳ组给ＤＭＢＡ前后分别给ＣＨＬ和ＢＣ。结果各组的肿瘤发生率分别为５０．０％，３３．３％，１８．３％和１７．４％。给ＢＣ组肿瘤发生率低于对照组（Ｐ＜０．０５），而单给ＣＨＬ组的肿瘤发生率与对照组比较差异无显著性（Ｐ＞０．０５），ＣＨＬ与ＢＣ合用组肿瘤发生率与Ⅲ组相似。说明ＢＣ确有抑制ＤＭＢＡ诱发乳腺癌的作用，而ＣＨＬ单用对ＤＭＢＡ的致癌作用无明显抑制，ＣＨＬ与ＢＣ合用也无协同或相加作用。The effect of β Carotene(BC) and chlorophyllin(CHL) on incidence of mammary tumor induced by dimethylben(a) antheracene(DMBA) in rats were investigated,50 days old female Sprague Dawley rats were randomly divided into 4 groups with 25 in each.Rats in group Ⅰ were administrated with DMBA 10mg/rat dissolved in corn oil by garage.Rats in

关 键 词：乳腺癌 Β-胡萝卜素 叶绿酸 二甲基苯蒽 

分 类 号：R737.902[医药卫生—肿瘤]