微波辐射下8-取代嘌呤核苷的绿色合成  

Green Synthesis of 8-Substituted Purine Nucleosides under Microwave Irradiation

作　　者：渠桂荣[1] 夏然[1] 杨西宁[1] 王东超[1] 

机构地区：[1]河南师范大学化学与环境科学学院,河南新乡453007

出　　处：《合成化学》2007年第6期756-758,762,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20772024)

摘　　要：8-溴嘌呤核苷与亲核试剂在水溶液中,于400W,95℃微波辐射5min合成了10种8-取代嘌呤核苷,收率72%～92%,其结构经1HNMR和13CNMR表征。8-Substituted purine nucleosides in yield of 72% - 92% were synthesized from 8-bromopurine nucleoside and nucleophilic reagent at 95 ℃ and 400 W under microwave irradiation for 5 min in water. The structures were characterized by ^1H NMR and ^13C NMR.

关 键 词：8-取代嘌呤 微波辐射 绿色合成 

分 类 号：R914.5[医药卫生—药物化学] O621.25[医药卫生—药学]