5-羟色胺1D基因多态与共患学习困难的儿童注意缺陷多动障碍的相关性  

Association between serotonin 1D gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid learning disorder

作　　者：李君[1] 王玉凤[1] 周儒伦[1] 杨莉[1] 张浩波[1] 汪冰[1] 

机构地区：[1]北京大学精神卫生研究所,北京100083

出　　处：《北京大学学报（医学版）》2007年第5期535-538,共4页Journal of Peking University:Health Sciences

基　　金：卫生部临床学科重点项目(2004-468);北京市科技计划项目(Y0204003040831);科技部攻关项目(Y0204003040831)基金资助~~

摘　　要：目的:探讨共患学习困难(LD)的儿童注意缺陷多动障碍(ADHD)与5-羟色胺1D受体基因(HTR1D)1350T>C和1236A>G两种多态之间的关联。方法:就91个共患LD的ADHD核心家系和181个不共患LD的ADHD核心家系的1350T>C和1236A>G两种多态进行检测,并分别进行传递不平衡(TDT)检验和单体型分析。结果:在不共患LD的家系中1236A等位基因(χ2=5.306,P=0.021,传递和未传递的次数分别为115和82)传递次数明显增加。在共患LD的家系中未发现任何等位基因和单体型的传递不平衡现象。结论:ADHD共患LD与否在HTR1D受体基因多态水平存在遗传差别,遗传在不共患LD的ADHD中具有更重要的作用。Objective：To investigate the relationship between two HTR1D gene polymorphisms,1350T〉C and 1236A〉G polymorphisms,and attention deficit hyperactivity disorder（ADHD）comorbid or not comorbid learning disorder（LD）.Methods：Blood samples were taken from 91 trios with probands of ADHD comrbid LD and 181 trios with probands of ADHD not comorbid LD.DNA was extracted.1350T〉C and 1236A〉G were genotyped by restriction fragment length polymorphism analysis.Transmit/disequilibrium test and haplotype analysis were used to test the association between the two polymorphisms of HTR1D gene and ADHD comorbid or not comorbid LD separately.Results：1236A allele（χ^2=5.306,P=0.021）was overtransmitted to probands of ADHD without LD.No biased transmissions of any allele and haplotype were found in families with probands of ADHD with LD.Conclusion：whether ADHD comorbid LD or not comorbid LD makes difference at the level of HTR1D gene polymrohisms of 1236A〉G.

关 键 词：注意缺陷和分裂性行为障碍 受体 血清素 基因 连锁不平衡 单元型 

分 类 号：R749.94[医药卫生—神经病学与精神病学]