阿司匹林对小型猪动脉粥样硬化的影响  

The Effects of Aspirin on Atherosclerosis in Miniature Pigs

作　　者：黄广勇[1] 谢忠忱[1] 李春海[1] 刘亚千[1] 郭雄明[1] 黄丽洁[1] 苟鹏[1] 陈华[1] 

机构地区：[1]中国人民解放军总医院医学实验动物中心,北京市100853

出　　处：《中国动脉硬化杂志》2007年第8期603-605,共3页Chinese Journal of Arteriosclerosis

基　　金："十五"国家科技攻关课题(2004BA717B)

摘　　要：目的探讨阿司匹林对早期动脉粥样硬化的干预作用。方法健康小型猪22头,随机分为对照组(n=6):给予正常猪饲料;高脂组(n=8):给予3%胆固醇高脂饮食;阿司匹林组(n=8):给予3%胆固醇高脂饮食+阿司匹林150 mg/d。高脂饮食4个月和6个月时,每组随机处死一半,定量测量动脉粥样硬化斑块厚度和斑块面积。结果3.0%胆固醇高脂饮食4个月就可以引起小型猪明显的动脉粥样硬化。高脂饮食4个月时,高脂组冠状动脉斑块厚度和截面积分别为107.2±45.7μm和0.113±0.05 mm2;阿司匹林组主动脉粥样硬化面积无明显减少,冠状动脉斑块厚度和截面积分别为74.2±24.7μm和0.093±0.05 mm2,与高脂组相比无统计学差异。高脂饮食6个月时,高脂组冠状动脉动脉粥样硬化斑块厚度为152.9±86.1μm、斑块/中膜厚度比0.85±0.49、斑块截面积为0.188±0.207 mm2、内膜/中膜面积比0.235±0.249;阿司匹林组主动脉粥样硬化面积明显减少,冠状动脉粥样硬化斑块厚度(47.8±19.8μm)、斑块/中膜厚度比(0.33±0.09)、斑块截面积(0.017±0.012 mm2)、内膜/中膜面积比(0.030±0.019),均明显低于高脂组(P<0.05或P<0.01)。结论阿司匹林对早期动脉粥样硬化有抑制作用。Aim To assess the effects of aspirin on early atherosclerosis. Methods 24-month-old miniature pigs were randomly assigned into three groups： control （ n = 6） which were fed on normal chow, 3.0% cholesterol group （ n = 8） which were fed on atherogenie diet containing 3.0% cholesterol, aspirin group （ n = 8） which were added aspirin 150 mg/d in 3% cholesterol group atherogenie diet. The athemgenie diet was continued for 6 months. Half pigs for each group were killed to determine the extent of atherosclerosis and the effects of aspirin after 4 months and 6 months. Results Cholesterol feeding induced significant artery atherosclerosis by 4 months. Morphometrie analysis showed the maximal intima thickness, intima area were 107.2 ± 45.7/ma and 0. 113 ± 0.05 mm^2 in 3% cholesterol group, 74.2 ± 24.7/ma and 0.093 ± 0.05 mm^2 in aspirin group in 4 months. Whereas at the end of 6 months, maximal intima tlfiekness, ratio of intima/media thickness, intima area and ratio of intima/media area were 152.9 ± 86.1 /ma, 0.85 ± 0.49, 0. 188 ± 0.207 mm^2 and 0.235 ± 0.249 in 3% cholesterol group, 47.8 ± 19.8 tun, 0.33 ± 0.09, 0.017 ± 0.012 mm^2 and 0. 030 ± 0.019 in aspirin group. The intima thickness, intima area had no statistic decline in 4 months but maikedly declined in 6 months in aspirin group compared with 3% cholesterol group （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Aspirin remarkably attenuated atherosclerosis plaque.

关 键 词：病理学与病理生理学 动脉粥样硬化 阿司匹林 小型猪 环氧合酶抑制剂 冠心病 

分 类 号：R363[医药卫生—病理学]