5-羟色胺4受体基因多态与共患破坏性行为障碍的儿童注意缺陷多动障碍的相关性  

Association between serotonin 4 gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid disruptive behavioral disorder

作　　者：李君[1] 王玉凤[1] 周儒伦[1] 杨莉[1] 张浩波[1] 汪冰[1] 

机构地区：[1]北京大学精神卫生研究所,北京100083

出　　处：《北京大学学报（医学版）》2007年第3期237-240,共4页Journal of Peking University:Health Sciences

基　　金：卫生部临床学科重点项目(2004-468);北京市科技计划项目(Y0204003040831);科技部攻关项目(2004BA720A20)基金资助~~

摘　　要：目的:探讨共患及不共患破坏性行为障碍(DBD)的儿童注意缺陷多动障碍(ADHD)与5-羟色胺4受体基因(HTR4)83097C>T、83198A>G及-36C>T三种多态之间的相关性。方法:对152个共患DBD的ADHD核心家系和173个不共患DBD的ADHD核心家系的83097C>T、83198A>G及-36C>T三种多态进行检测,并分别进行传递不平衡(TDT)检验和单体型分析。结果:在共患DBD的家系中,单体型T/G/T呈现传递增多的趋势(χ2=3.470,P=0.062),而在不共患DBD的家系中,单体型C/G/T(χ2=4.568,P=0.032)和C/G/C(χ2=5.333,P=0.021)均传递减少。无论在共患DBD的家系,还是在不共患DBD的家系中均未发现等位基因的传递不平衡现象。结论:ADHD共患DBD与否在HTR4多态水平存在遗传差别。Objective： To investigate the relationship between three HTR4 gene polymorphisms, 83097C 〉 T, 83198A 〉 G as well as -36C 〉 T polymorphisms, and attention deficit hyperactivity disorder （ADHD） comorbid or not comorbid disruptive behavioral disorder （DBD）. Methods： Blood samples were taken from 152 trios with probands of ADHD comrbid DBD and 173 trios with probands of ADHD not comorbid DBD. DNA was extracted. 83097C 〉 T, 83198A 〉 G and -36C 〉 T were genotyped by restriction fragment length polymorphism analysis. Transmit/disequilibrium test and haplotype analysis were used to test the association of the three polymorphisms with ADHD comorbid or not comorbid DBD separately. Results： Haplotype T/G/T showed tendency of overtransmission （ χ^2= 3. 470, P = 0. 062 ） to probands of ADHD with DBD, while haplotype C/G/T （ χ^2= 4. 568, P = 0. 032） and C/G/C （ χ^2= 5. 333, P =0. 021 ） were undertransmitted to probands of ADHD without DBD, No biased transmissions of any allele were found in families with probands of ADHD with and without DBD. Conclusion：whether ADHD comorbid DBD or not comorbid DBD makes difference at the level of HTR4 gene polymrohisms.

关 键 词：注意缺陷和破坏性行为障碍 受体 血清素 基因 连销不平衡 单元型 

分 类 号：R749.94[医药卫生—神经病学与精神病学]