体内外啤酒对血清酶活性的影响  

The effects of beer on the serum enzyme activities in vivo and vitro

作　　者：王泽平[1] 顾洪雁[1] 柏素云[1] 

机构地区：[1]泰山医学院生物化学教研室,山东泰安271000

出　　处：《泰山医学院学报》2007年第9期699-701,共3页Journal of Taishan Medical College

摘　　要：目的研究体内外啤酒对血清酶活性的影响。方法利用17名健康志愿者,观察口服啤酒(4 ml/kg)前后不同时间血液中酒精浓度及丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、肌酸激酶(CK)、乳酸脱氢酶(LDH)、淀粉酶(AMY)、脂肪酶(LIPA)活性的变化,同时在体外加入血清中与体内浓度相近的啤酒,以观察啤酒对酶活性的直接影响。结果啤酒在体内可使血清AST活性由(25.08±3.52)U/L降至(23.00±3.78)U/L,使血清ALP活性由(220.67±26.17)U/L升至(237.73±24.05)U/L。其余酶活性均有不同程度的升高。等浓度啤酒在体外对所有酶活性均有一定程度的抑制作用。结论体内外啤酒对血清酶活性均有一定的影响(P<0.01),在常规血清酶学检测中,应注意和避免饮用啤酒对检测结果的干扰。Objective ： To investigate the effects of beer on serum enzymes in vivo and vitro. Methods ： Serum alcohol and ALT, AST, GGT, ALP, CK, LDH, AMY, LIPA measured before and after beer consuming （ 4ml/kg ） in 17volunteers. Meanwhile, the direct inhibitory effects of beer on the serum enzymes were studied by comparing the serum enzyme activities with or without beer. Results ： Alcohol consuming could depress the serum AST activity from （25.08 ±3.52 ） U/L to （ 23.00±3.78 ） U/L and ALP activities from （220.67±26.17 ） U/L to （237.73±24.05 ） U/L. whereas increase the other serum enzyme activities. The inhibitory effects of beer on all the measured enzymes were found in vitro studies. Conclusions ： Beer could obvious influence the serum enzyme activities both in vivo and vitro. So avoiding the influence of serum enzyme activities after drinking beer is necessary.

关 键 词：啤酒 血清酶 干扰 

分 类 号：R363[医药卫生—病理学]