雷诺嗪的合成工艺改进  

Improved the Synthetic Method of Ranolazine

作　　者：郑晋鄂[1] 汤军[1] 罗智[1] 项光亚[1] 

机构地区：[1]华中科技大学同济医学院药学院,武汉430030

出　　处：《中国药师》2007年第12期1176-1177,共2页China Pharmacist

摘　　要：目的:合成抗心绞痛药雷诺嗪并进行工艺改进。方法:以邻甲氧基苯酚、2,6-二甲基苯胺为原料经过酰化、烃化、缩合、加成四步反应合成雷诺嗪。结果:所得产物化学结构经核磁共振氢谱及质谱确证,总收率为49.1%。结论:改进的合成工艺简便、合理且可行。Objective ： To synthesize ranolazine by improved method. Method ： Ranolazine was synthesized by 4 steps reaction of chloroacetylation,alkylation,condensation,and addition from 2,6-dimethylaniline. Result： Chemical structure of the product was confirmed by ^1H-NMR and MS. Total yield was 49.1%. Conclusion： This synthetic technique was simple,reasonable and feasible.

关 键 词：雷诺嗪 合成 工艺改进 

分 类 号：R914.5[医药卫生—药物化学]