水溶性丹参酮ⅡA的制备工艺研究  

STUDY ON THE PREPARATION OF WATER-SOLUBLE TANSHINONE ⅡA

作　　者：郭睿[1] 张春生[1] 姚占静[1] 包亮[1] 张艺钟[1] 

机构地区：[1]陕西科技大学化学与化工学院,陕西西安710021

出　　处：《陕西科技大学学报（自然科学版）》2007年第5期51-53,共3页Journal of Shaanxi University of Science & Technology

摘　　要：为改善丹参酮ⅡA在水中的溶解性,作者采用共沉淀法制备了β-环糊精与丹参酮ⅡA的固体包合物,使其在水中的溶解度提高了157倍,研究了反应物配比、温度、时间等因素对反应收率的影响,并用薄层色谱法和红外光谱法对固体包合物进行了表征.For improve the solubility of tanshinone Ⅱ A in the water,in this paper inclusion complexe of tanshinone Ⅱ A and β-CD was prepared using the method of coprecipitation method, solubility of tanshinone Ⅱ A in the water increased by157 times. The effects of reactant ratio, reaction temperature and time on the yield of inclusion complexes were researched . Stable inclusion complexes in solid state was characterized by infrared spectrum and TLC.

关 键 词：丹参酮ⅡA Β-环糊精 包合物 收率 

分 类 号：R914.4[医药卫生—药物化学]