儿童非酒精性脂肪性肝炎的配对病例对照研究  

A MATCHED CASE-CONTROL STUDY ON NON-ALCOHOLIC STEATOHEPATITIS IN CHILDREN

作　　者：孙桂香[1] 王健 董华 金英良[1] 徐继承[1] 陈颖 陆召军[1] 

机构地区：[1]徐州医学院公共卫生学系流行病与卫生统计学教研室,徐州221002 [2]徐州市医学科学研究所

出　　处：《现代预防医学》2007年第24期4670-4671,共2页Modern Preventive Medicine

摘　　要：[目的]探讨儿童非酒精性脂肪性肝炎(NASH)的危险因素。[方法]以人群调查为基础,采用嵌套1︰3配对病例对照研究方法,配对条件:年龄、性别和体重指数。对资料进行率、均数检验和条件Logistic回归分析。[结果]肥胖儿童NASH的患病率(10.74%)高于非肥胖儿童(2.62%,P﹤0.05);t检验及多因素条件回归分析发现:每周食用煎炸食品次数多(NASH组3.86±2.59,OR=2.271)、经常吃零食(OR=2.265)、母亲体重指数高[NASH组(24.69±3.13)kg/m2,OR=1.517]、每次食用水果量(NASH组4.62±2.80,OR=0.270)和家庭收入(OR=0.999)等5个独立危险或保护因素。[结论]儿童NASH尤其提倡早期预防及干预,减肥、多吃水果,少吃零食。[Objective]To explore the risk factors of non-alcoholic steatohepatitis（NASH） in children.[Methods]A population survey-based nested 1：3 matched case-control study paired by age,sex and body mass index（BMI） was conducted.Available data was analyzed by using t-test,Chi-square test,and conditional Logistic regression methods.[Results]The incidence of NASH in obese children（10.74%） was significantly higher than that in non-obese children（2.62%,P﹤0.05） ;After performing t-test and conditional Logistic regression,high frequency of fried food consumption in a week（NASH group 3.86 ± 2.59,OR = 2.271） ,high frequency of snacks consumption（OR = 2.265） ,high mother’s BMI（NASH Group 24.69 ± 3.13 kg/m2,OR = 1.517） ,consumption of fruits each time（NASH group 4.62 ± 2.80,OR = 0.270） and household income（OR = 0.999） appeared to be five independent risk factors or protective factors of NASH.[Conclusion]NASH in children should be prevented and intervened earlier.Moreover,reducing weight,and eating more fruit and less snacks,especially less fried food,can prevent and reduce NASH in children.

关 键 词：NASH 1︰3配对病例对照研究 条件LOGISTIC回归 

分 类 号：R575.1[医药卫生—消化系统]