人神经干细胞移植治疗重度视觉障碍脑瘫患儿的临床观察  

Treatment of Heteroptics after Cerebral Palsy with Transplantation of Human Neural Stem Cells into Cerebral Ventricle in Infants: 7 Case Report

作　　者：栾佐[1] 屈素清[1] 刘卫鹏[1] 胡晓红[1] 尹国才[1] 金真[2] 龚小军[1] 

机构地区：[1]海军总医院儿科,北京市100037 [2]解放军306医院,北京市100101

出　　处：《中国康复理论与实践》2007年第12期1103-1105,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的观察人神经干细胞(NSCs)移植治疗脑性瘫痪(CP)合并重度视觉障碍患儿的临床疗效。方法取孕11周正常发育人胚胎前脑细胞,经体外培养扩增为人神经干细胞球,并经前囟穿刺注入7例严重视觉障碍CP患儿的脑室。结果移植后,4例患儿在很短时间即出现视觉功能改善,伴有闪光视觉诱发电位、功能核磁的改变。结论人NSCs移植对部分重度视觉障碍脑瘫患儿有治疗作用。Objective To investigate the clinical effect of human neural stem cells transplantation on severe visual disability infants after cerebral palsy. Methods Cells obtained from the forebrain of an 11-week-old abortive fetus were cultured and expanded for 15 days, then injected into cerebral ventricle of 7 patients. Results Their vision of 4 patients improved, as well as changes of flash visual evoked potential and functional magnetic resonance imaging in a few days after transplantation. Conclusion Neural stem cells transplantation may benefit in some CP children with severe visual disability.

关 键 词：神经干细胞 移植 视觉障碍 脑性瘫痪 

分 类 号：R742.3[医药卫生—神经病学与精神病学]